UniProt Protein Function: | Seems to act as scaffold molecule at synaptic junctions by assembling neurotransmitter receptors and cell adhesion proteins. May play a role in regulating activin-mediated signaling in neuronal cells. Enhances the ability of PTEN to suppress AKT1 activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. |
UniProt Protein Details: | |
NCBI Summary: | The protein encoded by this gene interacts with atrophin-1. Atrophin-1 contains a polyglutamine repeat, expansion of which is responsible for dentatorubral and pallidoluysian atrophy. This encoded protein is characterized by two WW domains, a guanylate kinase-like domain, and multiple PDZ domains. It has structural similarity to the membrane-associated guanylate kinase homologue (MAGUK) family. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q86UL8 |
NCBI GenInfo Identifier: | 88909269 |
NCBI Gene ID: | 9863 |
NCBI Accession: | Q86UL8.3 |
UniProt Secondary Accession: | Q86UL8,O60434, O60510, Q86UI7, Q9NP44, Q9UDQ5, Q9UDU1 A4D1C1, A7E2C3 |
UniProt Related Accession: | Q86UL8 |
Molecular Weight: | 157,236 Da |
NCBI Full Name: | Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 |
NCBI Synonym Full Names: | membrane associated guanylate kinase, WW and PDZ domain containing 2 |
NCBI Official Symbol: | MAGI2Â Â |
NCBI Official Synonym Symbols: | AIP1; AIP-1; ARIP1; SSCAM; MAGI-2; ACVRIP1Â Â |
NCBI Protein Information: | membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 |
UniProt Protein Name: | Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 |
UniProt Synonym Protein Names: | Atrophin-1-interacting protein 1; AIP-1; Atrophin-1-interacting protein A; Membrane-associated guanylate kinase inverted 2; MAGI-2 |
Protein Family: | Membrane-associated guanylate kinase, WW and PDZ domain-containing protein |
UniProt Gene Name: | MAGI2Â Â |
UniProt Entry Name: | MAGI2_HUMAN |