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MAGI1 Antibody (PACO60316)

SKU:
PACO60316
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
IF
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€339

Description

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MAGI1 Antibody (PACO60316)

The MAGI1 Polyclonal Antibody (PACO60316) is a valuable tool for researchers studying MAGI1, a scaffolding protein involved in cell signaling and adhesion. This antibody, produced using rabbits as the host, exhibits high reactivity with human samples and has been validated for use in various applications, including Western blotting.MAGI1 is known to play a critical role in cell polarity, tight junction formation, and receptor signaling pathways. Its interactions with proteins involved in cell adhesion and signaling make it a key player in cellular processes, making it a promising target for research in cancer biology and cell biology.

By specifically binding to the MAGI1 protein, this antibody enables researchers to effectively detect and analyze MAGI1 expression in different cell types, providing valuable insights into its function and potential implications in disease development. Understanding the role of MAGI1 in cellular processes is crucial for advancing our knowledge of disease mechanisms and developing targeted therapies.

Antibody Name:MAGI1 Antibody (PACO60316)
Antibody SKU:PACO60316
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, IF
Recommended Dilutions:ELISA:1:2000-1:10000, IF:1:50-1:200
Species Reactivity:Human
Immunogen:Recombinant Human Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 protein (1234-1367AA)
Form:Liquid
Storage Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method:>95%, Protein G purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Product ImageImmunofluorescence staining of HepG2 cells with PACO60316 at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Background:May play a role as scaffolding protein at cell-cell junctions. May regulate acid, induced ASIC3 currents by modulating its expression at the cell surface (By similarity).
Synonyms:Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (Atrophin-1-interacting protein 3) (AIP-3) (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1) (Trinucleotide repeat-containing gene 19 protein) (WW domain-containing protein 3) (WWP3), MAGI1, AIP3 BAIAP1 BAP1 TNRC19
UniProt Protein Function:MAGI1: May play a role as scaffolding protein at cell-cell junctions. May regulate acid-induced ASIC3 currents by modulating its expression at the cell surface. 7 isoforms of the human protein are produced by alternative splicing.Protein type: Motility/polarity/chemotaxis; Cell adhesionChromosomal Location of Human Ortholog: 3p14.1Cellular Component: nucleoplasm; tight junction; cell projection; cytoplasm; plasma membrane; intercellular junction; cell junctionMolecular Function: protein C-terminus binding; protein binding; protein complex scaffold; alpha-actinin binding; ATP bindingBiological Process: cell surface receptor linked signal transduction; protein complex assembly; cell adhesion
UniProt Protein Details:
NCBI Summary:The protein encoded by this gene is a member of the membrane-associated guanylate kinase homologue (MAGUK) family. MAGUK proteins participate in the assembly of multiprotein complexes on the inner surface of the plasma membrane at regions of cell-cell contact. The product of this gene may play a role as scaffolding protein at cell-cell junctions. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
UniProt Code:Q96QZ7
NCBI GenInfo Identifier:74272284
NCBI Gene ID:9223
NCBI Accession:NP_001028229.1
UniProt Secondary Accession:Q96QZ7,O00309, O43863, O75085, Q96QZ8, Q96QZ9, A8K188
UniProt Related Accession:Q96QZ7
Molecular Weight:164,581 Da
NCBI Full Name:membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform c
NCBI Synonym Full Names:membrane associated guanylate kinase, WW and PDZ domain containing 1
NCBI Official Symbol:MAGI1  
NCBI Official Synonym Symbols:AIP3; BAP1; WWP3; AIP-3; BAP-1; BAIAP1; MAGI-1; Magi1d; TNRC19  
NCBI Protein Information:membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1; BAI1-associated protein 1; WW domain-containing protein 3; atrophin-1-interacting protein 3; membrane-associated guanylate kinase inverted 1; trinucleotide repeat-containing gene 19 protein
UniProt Protein Name:Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1
UniProt Synonym Protein Names:Atrophin-1-interacting protein 3; AIP-3; BAI1-associated protein 1; BAP-1; Membrane-associated guanylate kinase inverted 1; MAGI-1; Trinucleotide repeat-containing gene 19 protein; WW domain-containing protein 3; WWP3
Protein Family:Membrane-associated guanylate kinase, WW and PDZ domain-containing protein
UniProt Gene Name:MAGI1  
UniProt Entry Name:MAGI1_HUMAN
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