The MAGI1 Antibody (PAC010347) is a high-quality research tool designed for studying MAGI1, a protein involved in cellular signaling pathways and organization of cell junctions. This antibody, produced in-house, is highly specific to MAGI1 and has been validated for use in immunofluorescence and immunohistochemistry applications.MAGI1, also known as membrane-associated guanylate kinase with inverted domain structure 1, plays a critical role in the regulation of cell adhesion and signaling, making it a key player in processes such as cell proliferation, differentiation, and migration.
Dysregulation of MAGI1 has been linked to various diseases, including cancer and neurological disorders, highlighting its importance in cellular function.By using the MAGI1 Antibody in your research, you can explore the functions and mechanisms of MAGI1 in different cell types and tissues. This antibody provides a reliable tool for investigating the role of MAGI1 in normal physiological processes and disease development, ultimately advancing our understanding of cellular biology and potentially identifying new therapeutic targets.
MAGI1: May play a role as scaffolding protein at cell-cell junctions. May regulate acid-induced ASIC3 currents by modulating its expression at the cell surface. 7 isoforms of the human protein are produced by alternative splicing.Protein type: Motility/polarity/chemotaxis; Cell adhesionChromosomal Location of Human Ortholog: 3p14.1Cellular Component: nucleoplasm; tight junction; cell projection; cytoplasm; plasma membrane; intercellular junction; cell junctionMolecular Function: protein C-terminus binding; protein binding; protein complex scaffold; alpha-actinin binding; ATP bindingBiological Process: cell surface receptor linked signal transduction; protein complex assembly; cell adhesion
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is a member of the membrane-associated guanylate kinase homologue (MAGUK) family. MAGUK proteins participate in the assembly of multiprotein complexes on the inner surface of the plasma membrane at regions of cell-cell contact. The product of this gene may play a role as scaffolding protein at cell-cell junctions. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform c
NCBI Synonym Full Names:
membrane associated guanylate kinase, WW and PDZ domain containing 1
NCBI Official Symbol:
MAGI1Â Â
NCBI Official Synonym Symbols:
AIP3; BAP1; WWP3; AIP-3; BAP-1; BAIAP1; MAGI-1; Magi1d; TNRC19Â Â
NCBI Protein Information:
membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1; BAI1-associated protein 1; WW domain-containing protein 3; atrophin-1-interacting protein 3; membrane-associated guanylate kinase inverted 1; trinucleotide repeat-containing gene 19 protein
UniProt Protein Name:
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1
UniProt Synonym Protein Names:
Atrophin-1-interacting protein 3; AIP-3; BAI1-associated protein 1; BAP-1; Membrane-associated guanylate kinase inverted 1; MAGI-1; Trinucleotide repeat-containing gene 19 protein; WW domain-containing protein 3; WWP3
Protein Family:
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein
