The Magel2 Polyclonal Antibody (PAC019982) is a valuable tool for researchers studying Magel2, a protein involved in Prader-Willi syndrome (PWS) and other neurological disorders. This antibody, produced in rabbits, exhibits high specificity and sensitivity when detecting Magel2 in human samples, making it suitable for use in various applications such as Western blotting. By targeting the Magel2 protein, this antibody allows for the accurate detection and analysis of Magel2 expression in different cell types, facilitating research in neurology and genetic disorders.
Magel2, a member of the MAGE family of proteins, is known to play a key role in regulating circadian rhythm and body weight, factors that are disrupted in individuals with PWS. Research on Magel2 is important for understanding the underlying mechanisms of PWS and developing potential therapeutic interventions. The Magel2 Polyclonal Antibody provides researchers with a reliable tool to further investigate the functions and dysregulation of Magel2 in neurological disorders and other conditions.
Antibody Name:
MAGEL2 Antibody (PACO19982)
Antibody SKU:
PACO19982
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:1000-1:2000, WB:1:200-1:1000
Species Reactivity:
Human
Immunogen:
Synthetic peptide of human MAGEL2
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: Raji cells, Primary antibody: PACO19982(MAGEL2 Antibody) at dilution 1/250, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 minutes.
Background:
Prader-Willi syndrome (PWS) is caused by the loss of expression of imprinted genes in chromosome 15q11-q13 region. Affected individuals exhibit neonatal hypotonia, developmental delay, and childhood-onset obesity. Necdin (NDN), a gene involved in the terminal differentiation of neurons, localizes to this region of the genome and has been implicated as one of the genes responsible for the etiology of PWS. This gene is structurally similar to NDN, is also localized to the PWS chromosomal region, and is paternally imprinted, suggesting a possible role for it in PWS.
Synonyms:
MAGE-like 2
UniProt Protein Function:
MAGE-L2: May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. Interacts with TRIM27Chromosomal Location of Human Ortholog: 15q11.2Cellular Component: retromer complex; early endosome; nucleus; endosomeMolecular Function: protein binding; ubiquitin-protein ligase activityBiological Process: transcription, DNA-dependent; rhythmic process; negative regulation of transcription, DNA-dependent; regulation of circadian rhythm; retrograde transport, endosome to GolgiDisease: Prader-willi Syndrome; Prader-willi-like Syndrome
