The MAGED1 Antibody (PAC021424) is a valuable tool for research involving MAGE family proteins, specifically MAGE-D1, which is implicated in various cellular processes including cell growth, differentiation, and apoptosis. This polyclonal antibody, generated in rabbits, is highly specific to human samples and has been validated for use in Western blot and immunohistochemistry applications.MAGE-D1 is known to interact with p53 and modulate its activity, potentially impacting cell cycle regulation and tumorigenesis. Studies have suggested a possible role for MAGE-D1 in cancer progression, making it a target of interest for researchers investigating novel therapeutic strategies.
The MAGED1 antibody enables the detection and analysis of MAGE-D1 protein levels in different cell types, providing valuable insights into its function and potential as a cancer biomarker.With its high specificity and sensitivity, the MAGED1 Antibody is an essential tool for researchers studying MAGE-D1 and its implications in cancer biology and other cellular processes. Its ability to detect and analyze MAGE-D1 protein expression makes it a valuable asset in the fields of oncology and molecular biology, contributing to a better understanding of the role of MAGE family proteins in health and disease.
Antibody Name:
Maged1 Antibody (PACO21424)
Antibody SKU:
PACO21424
Size:
100ul
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:10000, WB:1:500-1:1000
Species Reactivity:
Mouse, Rat
Immunogen:
Peptide with sequence C-EAEARAEARNRMGIGDE derived from Mouse Melanoma-associated antigen D1.
Form:
Liquid
Storage Buffer:
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:
Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates Cheresh DA,et al. (1984) J Biol Chem.259(12):7453-9.
Clonality:
Polyclonal
Conjugate:
Non-conjugated
Western blot analysis of extracts from PC12 cells using Melanoma-associated antigen D1 Antibody and the same antibody preincubated with blocking peptide.
Synonyms:
MAGED1
UniProt Protein Function:
NRAGE: a member of the melanoma antigen gene (MAGE) family. Most of the genes of this family encode tumor specific antigens that are not expressed in normal adult tissues except testis. Although NRAGE shares strong homology with members of the MAGE family, it is expressed in almost all normal adult tissues. Binds p75 neurotrophin receptor (p75NTR) and antagonizes its association with TrkA, inhibits cell cycle progression, and facilitates p75NTR-mediated apoptosis. May act as a regulator of the function of DLX family members.Protein type: Adaptor/scaffoldCellular Component: protein complex; membrane; cytoplasm; plasma membrane; chromatin; nucleusMolecular Function: protein binding; transcription coactivator activityBiological Process: regulation of apoptosis; regulation of transcription from RNA polymerase II promoter; positive regulation of MAP kinase activity; positive regulation of transcription, DNA-dependent; rhythmic process; circadian regulation of gene expression; regulation of circadian rhythm; negative regulation of transcription, DNA-dependent; negative regulation of epithelial cell proliferation
