The MAGEC2 Antibody (PAC043871) is a highly specific polyclonal antibody designed for research involving MAGEC2, a protein associated with the MAGE family of cancer-testis antigens. This antibody is raised in rabbits and is validated for use in various applications, including Western blot and immunohistochemistry.MAGEC2 is known to play a role in cancer development and progression, making it a valuable target for cancer research. By detecting and analyzing MAGEC2 protein expression in various cell types, this antibody enables researchers to further understand the function and potential therapeutic targeting of MAGEC2 in cancer biology.
With its high reactivity with human samples, the MAGEC2 Antibody is a valuable tool for studying the molecular mechanisms underlying cancer progression and exploring new therapeutic strategies for cancer treatment. Researchers in the fields of oncology and molecular biology can benefit from the use of this antibody in their studies.
Antibody Name:
MAGEC2 Antibody (PACO43871)
Antibody SKU:
PACO43871
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:20-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human Melanoma-associated antigen C2 protein (1-150AA)
Form:
Liquid
Storage Buffer:
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Purification Method:
Antigen Affinity Purified
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Immunohistochemistry of paraffin-embedded human breast cancer using PACO43871 at dilution of 1:100.
Immunohistochemistry of paraffin-embedded human testis tissue using PACO43871 at dilution of 1:100.
Background:
Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. In vitro enhances ubiquitin ligase activity of TRIM28 and stimulates p53/TP53 ubiquitination in presence of Ubl-conjugating enzyme UBE2H leading to p53/TP53 degradation. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzymes (E2) at the E3:substrate complex.
MAGE-C2: Proposed to enhance ubiquitin ligase activity of RING- type zinc finger-containing E3 ubiquitin-protein ligases. In vitro enhances ubiquitin ligase activity of TRIM28 and stimulates p53/TP53 ubiquitination in presence of Ubl-conjugating enzyme UBE2H leading to p53/TP53 degradation. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzymes (E2) at the E3:substrate complex.Protein type: Cancer Testis Antigen (CTA)Chromosomal Location of Human Ortholog: Xq27Cellular Component: cytoplasm; nucleusMolecular Function: protein binding; ubiquitin protein ligase bindingBiological Process: cellular protein catabolic process; positive regulation of ubiquitin-protein ligase activity
UniProt Protein Details:
NCBI Summary:
This gene is a member of the MAGEC gene family. It is not expressed in normal tissues, except for testis, and is expressed in tumors of various histological types. This gene and the other MAGEC genes are clustered on chromosome Xq26-q27. [provided by RefSeq, Oct 2009]