MAGEC2 Antibody (PACO43871)
- SKU:
- PACO43871
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Frequently bought together:
Description
MAGEC2 Antibody (PACO43871)
The MAGEC2 Antibody (PAC043871) is a highly specific polyclonal antibody designed for research involving MAGEC2, a protein associated with the MAGE family of cancer-testis antigens. This antibody is raised in rabbits and is validated for use in various applications, including Western blot and immunohistochemistry.MAGEC2 is known to play a role in cancer development and progression, making it a valuable target for cancer research. By detecting and analyzing MAGEC2 protein expression in various cell types, this antibody enables researchers to further understand the function and potential therapeutic targeting of MAGEC2 in cancer biology.
With its high reactivity with human samples, the MAGEC2 Antibody is a valuable tool for studying the molecular mechanisms underlying cancer progression and exploring new therapeutic strategies for cancer treatment. Researchers in the fields of oncology and molecular biology can benefit from the use of this antibody in their studies.
| Antibody Name: | MAGEC2 Antibody (PACO43871) |
| Antibody SKU: | PACO43871 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Melanoma-associated antigen C2 protein (1-150AA) |
| Form: | Liquid |
| Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Purification Method: | Antigen Affinity Purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human breast cancer using PACO43871 at dilution of 1:100. |
 | Immunohistochemistry of paraffin-embedded human testis tissue using PACO43871 at dilution of 1:100. |
| Background: | Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. In vitro enhances ubiquitin ligase activity of TRIM28 and stimulates p53/TP53 ubiquitination in presence of Ubl-conjugating enzyme UBE2H leading to p53/TP53 degradation. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzymes (E2) at the E3:substrate complex. |
| Synonyms: | Melanoma-associated antigen C2 (Cancer/testis antigen 10) (CT10) (Hepatocellular carcinoma-associated antigen 587) (MAGE-C2 antigen) (MAGE-E1 antigen), MAGEC2, HCA587 MAGEE1 |
| UniProt Protein Function: | MAGE-C2: Proposed to enhance ubiquitin ligase activity of RING- type zinc finger-containing E3 ubiquitin-protein ligases. In vitro enhances ubiquitin ligase activity of TRIM28 and stimulates p53/TP53 ubiquitination in presence of Ubl-conjugating enzyme UBE2H leading to p53/TP53 degradation. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzymes (E2) at the E3:substrate complex.Protein type: Cancer Testis Antigen (CTA)Chromosomal Location of Human Ortholog: Xq27Cellular Component: cytoplasm; nucleusMolecular Function: protein binding; ubiquitin protein ligase bindingBiological Process: cellular protein catabolic process; positive regulation of ubiquitin-protein ligase activity |
| UniProt Protein Details: | |
| NCBI Summary: | This gene is a member of the MAGEC gene family. It is not expressed in normal tissues, except for testis, and is expressed in tumors of various histological types. This gene and the other MAGEC genes are clustered on chromosome Xq26-q27. [provided by RefSeq, Oct 2009] |
| UniProt Code: | Q9UBF1 |
| NCBI GenInfo Identifier: | 7706605 |
| NCBI Gene ID: | 51438 |
| NCBI Accession: | NP_057333.1 |
| UniProt Secondary Accession: | Q9UBF1,Q5JZ00, Q96D45, Q9P1M6, Q9P1M7 |
| UniProt Related Accession: | Q9UBF1 |
| Molecular Weight: | 41,163 Da |
| NCBI Full Name: | melanoma-associated antigen C2 |
| NCBI Synonym Full Names: | MAGE family member C2 |
| NCBI Official Symbol: | MAGEC2Â Â |
| NCBI Official Synonym Symbols: | CT10; HCA587; MAGEE1Â Â |
| NCBI Protein Information: | melanoma-associated antigen C2 |
| UniProt Protein Name: | Melanoma-associated antigen C2 |
| UniProt Synonym Protein Names: | Cancer/testis antigen 10; CT10; Hepatocellular carcinoma-associated antigen 587; MAGE-C2 antigen; MAGE-E1 antigen |
| Protein Family: | Melanoma-associated antigen |
| UniProt Gene Name: | MAGEC2Â Â |
| UniProt Entry Name: | MAGC2_HUMAN |
| Antibodies | ELISA Kits |
| MAGEC2 Antibody (PACO07101) | Human MAGEC2 (Melanoma-associated antigen C2) ELISA Kit (HUFI03542) |
| MAGEC2 Antibody (PACO10342) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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