The MAGEC2 Antibody (PAC02271) is a polyclonal antibody specifically designed for research involving MAGEC2, a cancer-testis antigen that plays a role in tumorigenesis. This antibody, produced in rabbits, shows high reactivity with human samples and has been validated for use in various applications, including Western blotting. By binding to the MAGEC2 protein, this antibody enables the detection and analysis of MAGEC2 expression in different cell types, making it a valuable tool for cancer research and immunotherapy studies.MAGEC2, also known as melanoma antigen family C2, is a promising target for cancer immunotherapy due to its restricted expression in cancer cells and the immune system's potential to recognize and attack MAGEC2-expressing tumors.
Research on MAGEC2's role in tumorigenesis and its interaction with the immune system is crucial for developing novel immunotherapies that target specific cancer cells while sparing normal tissues. The MAGEC2 Antibody provides researchers with a reliable tool to investigate these mechanisms and advance our understanding of cancer immunotherapy.
Antibody Name:
MAGEC2 Antibody (PACO22792)
Antibody SKU:
PACO22792
Size:
100ul
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:10000, WB:1:500-1:3000
Species Reactivity:
Human
Immunogen:
Synthesized peptide derived from internal of human MAGEC2.
Form:
Liquid
Storage Buffer:
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Western blot analysis of extracts from 293 cells, using MAGEC2 antibody.
Background:
Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. In vitro enhances ubiquitin ligase activity of TRIM28 and stimulates p53/TP53 ubiquitination in presence of Ubl-conjugating enzyme UBE2H leading to p53/TP53 degradation. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzymes (E2) at the E3:substrate complex.
MAGE-C2: Proposed to enhance ubiquitin ligase activity of RING- type zinc finger-containing E3 ubiquitin-protein ligases. In vitro enhances ubiquitin ligase activity of TRIM28 and stimulates p53/TP53 ubiquitination in presence of Ubl-conjugating enzyme UBE2H leading to p53/TP53 degradation. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzymes (E2) at the E3:substrate complex.Protein type: Cancer Testis Antigen (CTA)Chromosomal Location of Human Ortholog: Xq27Cellular Component: cytoplasm; nucleusMolecular Function: protein binding; ubiquitin protein ligase bindingBiological Process: cellular protein catabolic process; positive regulation of ubiquitin-protein ligase activity
UniProt Protein Details:
NCBI Summary:
This gene is a member of the MAGEC gene family. It is not expressed in normal tissues, except for testis, and is expressed in tumors of various histological types. This gene and the other MAGEC genes are clustered on chromosome Xq26-q27. [provided by RefSeq, Oct 2009]
