The MAGEC2 Antibody (PAC010342) is a valuable tool for researchers studying MAGEC2, a protein known to be involved in tumor development and progression. This polyclonal antibody, produced in rabbits, has been shown to have high reactivity with human samples and is suitable for use in Western blot applications. By specifically binding to the MAGEC2 protein, this antibody enables the detection and analysis of MAGEC2 in various cell types, making it an ideal choice for cancer research and immunology studies.
MAGEC2 is a cancer/testis antigen that is overexpressed in various types of cancer, including melanoma and lung cancer. Its role in promoting tumor growth and metastasis makes it a promising target for the development of novel cancer therapies. By using the MAGEC2 Antibody, researchers can gain valuable insights into the molecular mechanisms underlying cancer progression and potentially identify new therapeutic strategies for combating cancer.
melanoma antigen family C, 2;MAGEC2;CT10;HCA587;MAGEE1;MGC13377 ;
UniProt Protein Function:
MAGE-C2: Proposed to enhance ubiquitin ligase activity of RING- type zinc finger-containing E3 ubiquitin-protein ligases. In vitro enhances ubiquitin ligase activity of TRIM28 and stimulates p53/TP53 ubiquitination in presence of Ubl-conjugating enzyme UBE2H leading to p53/TP53 degradation. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzymes (E2) at the E3:substrate complex.Protein type: Cancer Testis Antigen (CTA)Chromosomal Location of Human Ortholog: Xq27Cellular Component: cytoplasm; nucleusMolecular Function: protein binding; ubiquitin protein ligase bindingBiological Process: cellular protein catabolic process; positive regulation of ubiquitin-protein ligase activity
UniProt Protein Details:
NCBI Summary:
This gene is a member of the MAGEC gene family. It is not expressed in normal tissues, except for testis, and is expressed in tumors of various histological types. This gene and the other MAGEC genes are clustered on chromosome Xq26-q27. [provided by RefSeq, Oct 2009]
