The MAGEC2 Antibody (PACO07101) is a polyclonal antibody specifically designed for research involving the MAGEC2 protein. MAGEC2 is a member of the melanoma-associated antigen (MAGE) family, known for its role in cancer development and progression. The antibody, generated using advanced technology, exhibits high specificity and sensitivity towards MAGEC2, making it an invaluable tool for studies in oncology and immunology.This antibody is well-suited for various applications, including Western blot, immunofluorescence, and immunohistochemistry, allowing for the detection and analysis of MAGEC2 expression in different cell types and tissues. Its ability to bind specifically to MAGEC2 enables researchers to investigate the function and regulation of this protein in cancer biology, with potential implications for targeted therapies and personalized medicine approaches.
With MAGEC2 being a promising target for cancer treatment and diagnosis, understanding its molecular mechanisms and signaling pathways is essential for advancing our knowledge of tumor biology and developing novel therapeutic strategies. The MAGEC2 Antibody (PACO07101) offers researchers a reliable tool to explore the role of MAGEC2 in cancer progression and its potential as a biomarker for predicting patient outcomes in clinical settings.
Antibody Name:
MAGEC2 Antibody (PACO07101)
Antibody SKU:
PACO07101
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:5000, WB:1:500-1:2000
Species Reactivity:
Human
Immunogen:
Synthesized peptide derived from the Internal region of human MAGE-C2.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Western Blot analysis of NIH-3T3 HuvEc Jurkat cells using MAGE-C2 Polyclonal Antibody.
Western blot analysis of mouse-brain HELA KB SH-SY5Y 293T 3T3 lysis using MAGE-C2 antibody.
Western Blot analysis of 293 cells using MAGE-C2 Polyclonal Antibody.
MAGE-C2: Proposed to enhance ubiquitin ligase activity of RING- type zinc finger-containing E3 ubiquitin-protein ligases. In vitro enhances ubiquitin ligase activity of TRIM28 and stimulates p53/TP53 ubiquitination in presence of Ubl-conjugating enzyme UBE2H leading to p53/TP53 degradation. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzymes (E2) at the E3:substrate complex.Protein type: Cancer Testis Antigen (CTA)Chromosomal Location of Human Ortholog: Xq27Cellular Component: cytoplasm; nucleusMolecular Function: protein binding; ubiquitin protein ligase bindingBiological Process: cellular protein catabolic process; positive regulation of ubiquitin-protein ligase activity
UniProt Protein Details:
NCBI Summary:
This gene is a member of the MAGEC gene family. It is not expressed in normal tissues, except for testis, and is expressed in tumors of various histological types. This gene and the other MAGEC genes are clustered on chromosome Xq26-q27. [provided by RefSeq, Oct 2009]
