The MAGEB4 Polyclonal Antibody (PAC014673) is a valuable tool for researchers studying MAGEB4, a member of the melanoma-associated antigen (MAGE) family commonly expressed in cancer cells. This antibody, raised in rabbits, exhibits high reactivity with human samples and is validated for use in immunohistochemistry and Western blot applications. By binding to the MAGEB4 protein, this antibody enables precise detection and analysis in a variety of cancer cell types, making it ideal for investigations in oncology research.MAGEB4 is known to play a crucial role in tumorigenesis and cancer progression, making it a promising target for the development of targeted therapies and diagnostic tools. Its expression has been linked to various cancer types, including melanoma and lung cancer, highlighting its potential as a biomarker for cancer detection and prognosis.
By studying the function of MAGEB4, researchers can gain valuable insights into the mechanisms driving cancer development and explore new strategies for personalized treatment approaches. Overall, the MAGEB4 Polyclonal Antibody (PAC014673) serves as a valuable resource for researchers aiming to unravel the complexities of cancer biology and develop innovative strategies for cancer diagnosis and treatment. Its high specificity and sensitivity make it a reliable tool for advancing our understanding of MAGEB4 and its implications in cancer research.
The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using PACO14673(MAGEB4 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: x200).
Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: Lncap cells, Primary antibody: PACO14673(MAGEB4 Antibody) at dilution 1/700, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds.
The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using PACO14673(MAGEB4 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: x200).
Background:
This gene is a member of the MAGEB gene family. The members of this family have their entire coding sequences located in the last exon, and the encoded proteins show 50 to 68 sequence identity to each other. The promoters and first exons of the MAGEB genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEB genes are clustered on chromosome Xp22-p21. This gene sequence ends in the first intron of MAGEB1, another family member. This gene is expressed in testis.
Synonyms:
melanoma antigen family B, 4
UniProt Protein Function:
MAGE-B4:
UniProt Protein Details:
Protein type:Cancer Testis Antigen (CTA)
Chromosomal Location of Human Ortholog: Xp21.3
NCBI Summary:
This gene is a member of the MAGEB gene family. The members of this family have their entire coding sequences located in the last exon, and the encoded proteins show 50 to 68% sequence identity to each other. The promoters and first exons of the MAGEB genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEB genes are clustered on chromosome Xp22-p21. This gene sequence ends in the first intron of MAGEB1, another family member. This gene is expressed in testis. [provided by RefSeq, Jul 2008]
