The MAGEB4 Polyclonal Antibody (PAC014672) is a valuable tool for researchers studying MAGEB4, a member of the melanoma-associated antigen (MAGE) family that is involved in multiple cellular processes, including cell proliferation and apoptosis. This rabbit-raised antibody is specifically designed for use in Western blot applications and exhibits high reactivity with human samples.MAGEB4 is known to be upregulated in various cancers, making it a potential target for cancer therapy development. By binding to the MAGEB4 protein, this antibody allows for the detection and analysis of MAGEB4 expression in diverse cell types, making it ideal for studies in oncology and cancer biology.
Understanding the role of MAGEB4 in cancer progression is essential for the development of targeted therapies that can effectively inhibit its oncogenic functions. By using the MAGEB4 Polyclonal Antibody, researchers can gain valuable insights into the mechanisms underlying MAGEB4-mediated tumorigenesis, paving the way for innovative approaches in cancer treatment.
The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using PACO14672(MAGEB4 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: x200).
Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: Human brain glioma tissue, Primary antibody: PACO14672(MAGEB4 Antibody) at dilution 1/550, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes.
The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO14672(MAGEB4 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: x200).
Background:
This gene is a member of the MAGEB gene family. The members of this family have their entire coding sequences located in the last exon, and the encoded proteins show 50 to 68 sequence identity to each other. The promoters and first exons of the MAGEB genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEB genes are clustered on chromosome Xp22-p21. This gene sequence ends in the first intron of MAGEB1, another family member. This gene is expressed in testis.
Synonyms:
melanoma antigen family B, 4
UniProt Protein Function:
MAGE-B4:
UniProt Protein Details:
Protein type:Cancer Testis Antigen (CTA)
Chromosomal Location of Human Ortholog: Xp21.3
NCBI Summary:
This gene is a member of the MAGEB gene family. The members of this family have their entire coding sequences located in the last exon, and the encoded proteins show 50 to 68% sequence identity to each other. The promoters and first exons of the MAGEB genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEB genes are clustered on chromosome Xp22-p21. This gene sequence ends in the first intron of MAGEB1, another family member. This gene is expressed in testis. [provided by RefSeq, Jul 2008]
