The MAGEB2 Monoclonal Antibody (PACO19970) is a valuable tool for researchers studying MAGEB2, a member of the melanoma-associated antigen (MAGE) family that is involved in tumor growth and progression. This antibody, produced through hybridoma technology, demonstrates high specificity and sensitivity for detecting MAGEB2 in human samples, making it suitable for use in various immunoassays.MAGEB2 is known to be overexpressed in a variety of cancers, including melanoma and prostate cancer, and its role in promoting tumor cell proliferation and survival makes it an attractive target for cancer research.
By targeting MAGEB2 with this antibody, researchers can investigate its functions and potential as a therapeutic target in cancer treatment.This monoclonal antibody opens up opportunities for studying the molecular mechanisms underlying MAGEB2's oncogenic properties and may lead to the development of novel cancer therapies aimed at disrupting its activity. Its reliability and specificity make it an essential tool for advancing our understanding of MAGEB2 and its implications in cancer biology.
Antibody Name:
MAGEB2 Antibody (PACO19970)
Antibody SKU:
PACO19970
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:25-1:100
Species Reactivity:
Human
Immunogen:
Synthetic peptide of human MAGEB2
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO19970(MAGEB2 Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
This gene is a member of the MAGEB gene family. The members of this family have their entire coding sequences located in the last exon, and the encoded proteins show 50 to 68% sequence identity to each other. The promoters and first exons of the MAGEB genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. This gene is localized in the DSS (dosage-sensitive sex reversal) critical region. It is expressed in testis and placenta, and in a significant fraction of tumors of various histological types. The MAGEB genes are clustered on chromosome Xp22-p21.
Synonyms:
melanoma antigen family B, 2
UniProt Protein Function:
May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex.
UniProt Protein Details:
NCBI Summary:
This gene is a member of the MAGEB gene family. The members of this family have their entire coding sequences located in the last exon, and the encoded proteins show 50 to 68% sequence identity to each other. The promoters and first exons of the MAGEB genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. This gene is localized in the DSS (dosage-sensitive sex reversal) critical region. It is expressed in testis and placenta, and in a significant fraction of tumors of various histological types. The MAGEB genes are clustered on chromosome Xp22-p21. [provided by RefSeq, Jul 2008]
