The MAGEB18 Polyclonal Antibody (PAC019974) is a valuable tool for researchers studying MAGEB18, a member of the melanoma-associated antigen (MAGE) family. This antibody, produced in rabbits, exhibits high reactivity with human samples and is specifically validated for use in immunohistochemistry applications. By binding to the MAGEB18 protein, this antibody allows for precise detection and analysis in various cell types, making it an essential tool for investigations in cancer biology and immunotherapy.MAGEB18 is a potential target for cancer therapy due to its involvement in tumor development and progression. As a member of the MAGE family, MAGEB18 is known to play a role in immune evasion and tumorigenesis, making it an attractive candidate for targeted therapies.
Understanding the function and expression of MAGEB18 is crucial for developing novel treatment strategies and improving outcomes for cancer patients.Overall, the MAGEB18 Polyclonal Antibody offers researchers a reliable and sensitive tool for investigating the role of MAGEB18 in cancer biology and immunotherapy. Its specificity and reactivity make it well-suited for a variety of research applications, providing valuable insights into the biology of cancer and potential therapeutic targets.
Antibody Name:
MAGEB18 Antibody (PACO19974)
Antibody SKU:
PACO19974
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:50-1:200
Species Reactivity:
Human
Immunogen:
Synthetic peptide of human MAGEB18
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO19974(MAGEB18 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO19974(MAGEB18 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
The melanoma-associated antigen (MAGE) family consists of a number of antigens recognized by cytotoxic T lymphocytes. The MAGE genes were initially isolated from different kinds of tumors and, based on their virtually exclusive tumor-specific expression in adult tissues, they have been used as targets for cancer immunotherapy. MAGE genes encode for tumor-rejection antigens that are expressed in tumors of different histologic types and in normal testis and placenta. MAGE-B18 (melanoma-associated antigen B18) is a 343 amino acid, protein that contains one MAGE domain and may be involved in tumorigenesis. The gene encoding MAGE-B18 maps to human chromosome X, which contains nearly 153 million base pairs and houses over 1,000 genes.
