The MAGEA8 Monoclonal Antibody (PAC028114) is a powerful tool for researchers studying MAGEA8, a member of the MAGE protein family that is associated with cancer development and progression. This antibody, produced in mice, is highly specific to human MAGEA8 and has been validated for use in various research applications, including immunohistochemistry and flow cytometry.MAGEA8 is known to play a role in promoting tumorigenesis and metastasis in various types of cancer, making it a promising target for cancer therapy development.
By targeting MAGEA8, researchers can gain valuable insights into the mechanisms underlying cancer progression and potentially identify new therapeutic strategies for combating cancer.Overall, the MAGEA8 Monoclonal Antibody (PAC028114) is a valuable tool for investigating the role of MAGEA8 in cancer biology and may ultimately lead to the development of novel therapeutic approaches for treating cancer.
Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression.
UniProt Protein Details:
NCBI Summary:
This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Oct 2009]
