The MAGEA8 Polyclonal Antibody (PAC010338) is a valuable tool for researchers studying MAGEA8, a member of the MAGE family of cancer-testis antigens. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By binding specifically to the MAGEA8 protein, researchers can detect and analyze its expression in various cell types, making it ideal for studies in cancer research and immunotherapy.
MAGEA8, a potential cancer biomarker, is known for its role in promoting tumorigenesis and cancer progression. Its overexpression has been linked to various types of cancer, making it an attractive target for therapeutic development. By understanding the function and expression of MAGEA8, researchers can gain valuable insights into cancer biology and potentially develop targeted therapies for MAGEA8-positive tumors.
melanoma antigen family A, 8;MAGEA8;CT1.8;MAGE8;MGC2182 ;
UniProt Protein Function:
Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression.
UniProt Protein Details:
NCBI Summary:
This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Oct 2009]
