The MAGEA5 Antibody (PACO02887) is a valuable tool for research involving the MAGEA5 protein, a member of the MAGEA family known to be involved in cancer development and progression. This polyclonal antibody, produced from rabbit hosts, is highly specific and reactive with human samples, making it ideal for Western blot applications. By binding to the MAGEA5 protein, researchers can detect and analyze its expression in various cell types, providing insights into its role in cancer biology.MAGEA5 is a tumor-specific antigen that is overexpressed in various cancer types, including melanoma, lung cancer, and breast cancer. Its aberrant expression has been implicated in promoting tumorigenesis and metastasis, making it a promising target for cancer therapy development.
By studying the expression and function of MAGEA5, researchers can uncover new therapeutic strategies for targeting cancer cells while sparing normal tissues.Overall, the MAGEA5 Antibody (PACO02887) is a valuable tool for scientists investigating the role of MAGEA5 in cancer biology. Its high specificity and sensitivity make it a reliable reagent for studying the expression and function of MAGEA5 in various cancer models, paving the way for the development of novel cancer treatments.
Antibody Name:
MAGEA5 Antibody
Antibody SKU:
PACO02887
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
WB:1:500-1:2000
Species Reactivity:
Human
Immunogen:
synthesized peptide derived from the Internal region of human MAGE-A5.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. This MAGEA gene encodes a protein that is C-terminally truncated compared to other family members, and this gene can be alternatively interpreted to be a pseudogene. The protein is represented in this Gene record in accordance with the assumed protein-coding status defined in the literature. Read-through transcription exists between this gene and the upstream melanoma antigen family A, 10 (MAGEA10) gene. [provided by RefSeq, Oct 2011]
