Anti-MAGEA10 Antibody (PACO16643)

Antibody Name:	MAGEA10 Antibody (PACO16643)
Antibody SKU:	PACO16643
Size:	50ul
Host Species:	Rabbit
Tested Applications:	ELISA, WB, IHC
Recommended Dilutions:	ELISA:1:2000-1:5000, WB:1:500-1:2000, IHC:1:25-1:100
Species Reactivity:	Human
Immunogen:	Fusion protein of human MAGEA10

Form:	Liquid
Storage Buffer:	-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:	Antigen affinity purification
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

	Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: A375 cells, Primary antibody: PACO16643(MAGEA10 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds.
	The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using PACO16643(MAGEA10 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200).

Background:

This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. Alternative splicing results in multiple transcript variants.

Synonyms:

melanoma antigen family A, 10

UniProt Protein Function:	MAGE-A10: Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression.Chromosomal Location of Human Ortholog: Xq28Cellular Component: nucleus
UniProt Protein Details:
NCBI Summary:	This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. Two transcript variants encoding the same protein have been found for this gene. Read-through transcription also exists between this gene and the downstream melanoma antigen family A, 5 (MAGEA5) gene.[provided by RefSeq]
UniProt Code:	P43363
NCBI GenInfo Identifier:	10567820
NCBI Gene ID:	4109
NCBI Accession:	NP_066386.1
UniProt Secondary Accession:	P43363
UniProt Related Accession:	P43363
Molecular Weight:	40,780 Da
NCBI Full Name:	melanoma-associated antigen 10
NCBI Synonym Full Names:	melanoma antigen family A, 10
NCBI Official Symbol:	MAGEA10
NCBI Official Synonym Symbols:	CT1.10; MAGE10; MGC10599
NCBI Protein Information:	melanoma-associated antigen 10; MAGE-10 antigen; OTTHUMP00000025894; OTTHUMP00000025895; OTTHUMP00000025896; cancer/testis antigen 1.10; cancer/testis antigen family 1, member 10
UniProt Protein Name:	Melanoma-associated antigen 10
UniProt Synonym Protein Names:	Cancer/testis antigen 1.10; CT1.10; MAGE-10 antigen
Protein Family:
UniProt Gene Name:	MAGEA10
UniProt Entry Name:	MAGAA_HUMAN

Antibodies

MAGEA10 Antibody (PACO10334)

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)