The MAGEA10 Monoclonal Antibody (PACO16643) is a vital tool for researchers studying MAGEA10, a member of the MAGEA family of cancer/testis antigens. This antibody, produced using innovative technology, exhibits high specificity and sensitivity for human samples and is suitable for use in various applications such as Western blotting and immunohistochemistry.MAGEA10 is known for its role in cancer development and progression, particularly in lung and breast cancers. It is also associated with resistance to chemotherapy, making it an attractive target for therapeutic interventions. By utilizing the MAGEA10 Monoclonal Antibody, researchers can explore the expression and function of MAGEA10 in cancer cells, leading to a deeper understanding of its impact on tumorigenesis and potential as a therapeutic target.
With its superior performance and reliability, the MAGEA10 Monoclonal Antibody is an invaluable asset for researchers investigating the biological functions of MAGEA10 and its implications for cancer diagnosis and treatment. By providing detailed insights into the role of MAGEA10 in oncogenesis, this antibody facilitates the development of targeted therapies that could improve patient outcomes in the future.
Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: A375 cells, Primary antibody: PACO16643(MAGEA10 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds.
The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using PACO16643(MAGEA10 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200).
Background:
This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. Alternative splicing results in multiple transcript variants.
Synonyms:
melanoma antigen family A, 10
UniProt Protein Function:
MAGE-A10: Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression.Chromosomal Location of Human Ortholog: Xq28Cellular Component: nucleus
UniProt Protein Details:
NCBI Summary:
This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. Two transcript variants encoding the same protein have been found for this gene. Read-through transcription also exists between this gene and the downstream melanoma antigen family A, 5 (MAGEA5) gene.[provided by RefSeq]
