The MAGEA1 Polyclonal Antibody (CAB5470) is a valuable tool for researchers studying MAGEA1, a member of the MAGEA gene family that plays a role in cancer development and progression. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By binding to the MAGEA1 protein, this antibody allows for the detection and analysis of MAGEA1 expression in various cell types, making it ideal for studies in oncology and cancer biology.MAGEA1 is known to be involved in various cellular processes, including cell proliferation, survival, and differentiation, and its overexpression has been linked to tumorigenesis and metastasis in multiple cancer types.
Understanding the function and regulation of MAGEA1 is crucial for developing targeted therapies and diagnostic tools for cancer patients. By utilizing the MAGEA1 Polyclonal Antibody, researchers can further explore the role of MAGEA1 in cancer biology and potentially identify novel therapeutic targets for cancer treatment.
Product Name:
MAGE-1/MAGE1A Rabbit Polyclonal Antibody
SKU:
CAB5470
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-309 of human MAGE-1/MAGE1A (NP_004979.3).
This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita.
Purification Method:
Affinity purification
Gene ID:
4100
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of lysates from 22Rv1 cells, using MAGE-1/MAGE1A Rabbit pAb (CAB5470) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
