The MAFK Polyclonal Antibody (CAB17551) is a valuable tool for researchers studying the MAFK protein, a transcription factor involved in various cellular processes, including cell differentiation, proliferation, and apoptosis. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications.MAFK is known to play a crucial role in regulating gene expression and cellular responses to stimuli, making it a key player in the regulation of cell growth and differentiation.
Its involvement in important signaling pathways makes it a target of interest for researchers studying cancer, inflammation, and other diseases.With the ability to specifically bind to the MAFK protein, this antibody enables researchers to detect and analyze MAFK expression in a variety of cell types, providing valuable insights into the molecular mechanisms controlled by this transcription factor. Its versatility makes it an essential tool for studies in molecular biology, cancer biology, and developmental biology.
Product Name:
MAFK Rabbit Polyclonal Antibody
SKU:
CAB17551
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-50 of human MAFK (NP_002351.1).
The developmentally regulated expression of the globin genes depends on upstream regulatory elements termed locus control regions (LCRs). LCRs are associated with powerful enhancer activity that is mediated by the transcription factor NFE2 (nuclear factor erythroid-2). NFE2 recognition sites are also present in the gene promoters of 2 heme biosynthetic enzymes, porphobilinogen deaminase (PBGD; MIM 609806) and ferrochelatase (FECH; MIM 612386). NFE2 DNA-binding activity consists of a heterodimer containing an 18-kD Maf protein (MafF, MafG (MIM 602020), or MafK) and p45 (MIM 601490). Both subunits are members of the activator protein-1 superfamily of basic leucine zipper (bZIP) proteins (see MIM 165160). Maf homodimers suppress transcription at NFE2 sites.
Purification Method:
Affinity purification
Gene ID:
7975
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using MAFK Rabbit pAb (CAB17551) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
