The MAF1 Polyclonal Antibody (CAB15531) is a valuable tool for researchers studying the MAF1 protein, a key regulator of RNA polymerase III-mediated transcription. This antibody is produced in rabbits and exhibits high reactivity with human samples. Validated for use in Western blot applications, it specifically binds to the MAF1 protein, allowing for accurate detection and analysis in various cell types.MAF1 is involved in controlling the expression of genes responsible for the production of transfer RNA and ribosomal RNA, making it essential for the regulation of cellular growth and metabolism.
Dysregulation of MAF1 has been linked to diseases such as cancer, metabolic disorders, and neurological conditions. Research on MAF1 can provide insights into the mechanisms underlying these diseases and potentially lead to the development of targeted therapies.By utilizing the MAF1 Polyclonal Antibody, researchers can enhance their studies in molecular biology, genetics, and oncology. This antibody offers a valuable resource for investigating the functions of MAF1 and its implications in various physiological and pathological processes.
Product Name:
MAF1 Rabbit Polyclonal Antibody
SKU:
CAB15531
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-256 of human MAF1 (NP_115648.2).
This gene encodes a protein that is similar to Maf1, a Saccharomyces cerevisiae protein highly conserved in eukaryotic cells. Yeast Maf1 is a negative effector of RNA polymerase III (Pol III). It responds to changes in the cellular environment and represses pol III transcription. Biochemical studies identified the initiation factor TFIIIB as a target for Maf1-dependent repression.
Purification Method:
Affinity purification
Gene ID:
84232
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using MAF1 Rabbit pAb (CAB15531) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
