The MadCAM-1 Polyclonal Antibody is a valuable tool for researchers studying MadCAM-1, a cell adhesion molecule involved in immune cell trafficking to the gut. This antibody, raised in rabbits, exhibits high reactivity with human samples and is validated for use in various applications including Western blot and immunofluorescence.MadCAM-1 plays a vital role in the recruitment of lymphocytes to the gut-associated lymphoid tissue, making it a key player in immune surveillance and response in the gastrointestinal system. Research on MadCAM-1 has implications for understanding and potentially targeting inflammatory bowel diseases, such as Crohn's disease and ulcerative colitis.
By using the MadCAM-1 Polyclonal Antibody, researchers can detect and analyze MadCAM-1 expression in different cell types and tissues, aiding in the investigation of immune responses and inflammatory processes in the gut. This antibody is a valuable tool for advancing our understanding of gut immune regulation and developing new therapeutic strategies for gastrointestinal disorders.
Product Name:
MAdCAM-1 Polyclonal Antibody
SKU:
CAB24489
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 22-109 of mouse MAdCAM-1 (NP_038619.2).
Predicted to enable integrin binding activity involved in cell-matrix adhesion. Acts upstream of or within keratinocyte differentiation and leukocyte migration. Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in eyelid; hair follicle; and hemolymphoid system. Orthologous to human MADCAM1 (mucosal vascular addressin cell adhesion molecule 1).
Purification Method:
Affinity purification
Gene ID:
17123
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of Mouse small intestine, using MAdCAM-1 Rabbit pAb (CAB24489) at 1:700 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
