The MAD2L2 Polyclonal Antibody (CAB12559) is a valuable tool for researchers studying the MAD2L2 protein, a key player in cell cycle regulation and cell division processes. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the MAD2L2 protein, this antibody enables precise detection and analysis in various cell types, making it ideal for investigations in cell biology and cancer research.MAD2L2, also known as mitotic spindle assembly checkpoint protein, is essential for ensuring accurate chromosome segregation during cell division.
Dysregulation of MAD2L2 can lead to genomic instability, a hallmark of cancer development. Research into the function of MAD2L2 is critical for understanding the mechanisms underlying tumorigenesis and identifying potential targets for anti-cancer therapies.The MAD2L2 Polyclonal Antibody provides researchers with a reliable tool for studying the role of MAD2L2 in cellular processes and disease pathology. Its high specificity and sensitivity make it a valuable asset for advancing our knowledge of cancer biology and exploring potential therapeutic interventions.
Product Name:
MAD2B/MAD2L2 Rabbit Polyclonal Antibody
SKU:
CAB12559
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-211 of human MAD2B/MAD2B/MAD2L2 (NP_006332.3).
The protein encoded by this gene is a component of the mitotic spindle assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. The encoded protein, which is similar to MAD2L1, is capable of interacting with ADAM9, ADAM15, REV1, and REV3 proteins.
Purification Method:
Affinity purification
Gene ID:
10459
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using MAD2B/MAD2B/MAD2L2 antibody (CAB12559) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
