The MAD2L1 Polyclonal Antibody (CAB16911) is specifically designed for research involving MAD2L1, a crucial protein involved in cell division and the regulation of the cell cycle. This antibody, which is raised in rabbits, is highly reactive with human samples and has been validated for use in Western blot applications. By binding to the MAD2L1 protein, this antibody enables researchers to detect and analyze MAD2L1 in various cell types, making it an ideal tool for studies in cell biology, cancer research, and genetics.MAD2L1, also known as Mitotic Arrest Deficient 2 Like 1, is essential for proper chromosome segregation during cell division and plays a critical role in maintaining genomic stability.
Dysregulation of MAD2L1 has been linked to cancer development and progression, making it a promising target for cancer therapeutics. Additionally, understanding the function of MAD2L1 is crucial for uncovering its role in genetic disorders and developmental abnormalities associated with cell division.The MAD2L1 Polyclonal Antibody offers researchers a reliable tool for studying the function and regulation of MAD2L1 in various cellular processes, providing valuable insights into the mechanisms underlying cell division and the potential impacts on disease development.
Product Name:
MAD2/MAD2L1 Rabbit Polyclonal Antibody
SKU:
CAB16911
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-205 of human MAD2/MAD2/MAD2L1 (NP_002349.1).
Chromosome, Cytoplasm, Nucleus, centromere, cytoskeleton, kinetochore, spindle pole.
Calculated MW:
24kDa
Observed MW:
27kDa
MAD2L1 is a component of the mitotic spindle assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. MAD2L1 is related to the MAD2L2 gene located on chromosome 1. A MAD2 pseudogene has been mapped to chromosome 14.
Purification Method:
Affinity purification
Gene ID:
4085
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using MAD2/MAD2/MAD2L1 Rabbit pAb (CAB16911) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
