The MAD2L1 Rabbit Monoclonal Antibody is a cutting-edge tool for researchers studying MAD2L1, a protein known for its role in the cell cycle and cell division processes. This antibody, produced in rabbits, demonstrates high specificity and sensitivity towards MAD2L1 in human samples, making it a reliable tool for Western blotting applications.MAD2L1, also known as mitotic arrest deficient 2 like 1, is a key player in the spindle assembly checkpoint, ensuring the accurate segregation of chromosomes during cell division. Dysregulation of MAD2L1 has been linked to various diseases, including cancer, making it a promising target for therapeutic interventions.
By utilizing the MAD2L1 Rabbit Monoclonal Antibody, researchers can efficiently detect and study MAD2L1 expression in different cell types, advancing our understanding of its functions and potential implications in diseases. This antibody is a valuable resource for investigations in cell biology, cancer research, and drug development aiming to target the cell cycle for therapeutic purposes.
Product Name:
MAD2/MAD2L1 Rabbit Monoclonal Antibody
SKU:
CAB11469
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 70-150 of human MAD2/MAD2L1 (Q13257).
Chromosome, Cytoplasm, Nucleus, centromere, cytoskeleton, kinetochore, spindle pole.
Calculated MW:
24kDa
Observed MW:
24kDa
MAD2L1 is a component of the mitotic spindle assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. MAD2L1 is related to the MAD2L2 gene located on chromosome 1. A MAD2 pseudogene has been mapped to chromosome 14.
Purification Method:
Affinity purification
Gene ID:
4085
Clone Number:
ARC0603
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using MAD2/MAD2/MAD2L1 Rabbit mAb (CAB11469) at 1：1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3min.
