The MAD2L1 Polyclonal Antibody (CAB16395) is a key tool for researchers studying MAD2L1, a crucial protein involved in cell cycle progression and mitotic checkpoint control. This antibody, generated in rabbits, is highly specific to human samples and has been rigorously validated for use in Western blotting applications. By binding to MAD2L1 protein, this antibody enables precise detection and analysis in various cell types, making it an essential asset for studies in cell biology and cancer research.
MAD2L1, also known as mitotic arrest deficient 2-like 1, plays a pivotal role in ensuring accurate chromosome segregation during cell division. Dysregulation of MAD2L1 has been implicated in various human cancers, making it a compelling target for therapeutic intervention. By elucidating the mechanisms underlying MAD2L1 function, researchers can gain insights into potential strategies for targeting this protein in cancer treatment and other disease contexts.
Product Name:
MAD2/MAD2L1 Rabbit Polyclonal Antibody
SKU:
CAB16395
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-205 of human MAD2/MAD2/MAD2L1 (NP_002349.1).
Chromosome, Cytoplasm, Nucleus, centromere, cytoskeleton, kinetochore, spindle pole.
Calculated MW:
24kDa
MAD2L1 is a component of the mitotic spindle assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. MAD2L1 is related to the MAD2L2 gene located on chromosome 1. A MAD2 pseudogene has been mapped to chromosome 14.
Purification Method:
Affinity purification
Gene ID:
4085
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Immunohistochemistry analysis of paraffin-embedded mouse testis using MAD2/MAD2L1 Rabbit pAb (CAB16395) at dilution of 1:100 (40x lens).Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
