The MAD1L1 Polyclonal Antibody is a valuable tool for researchers studying the MAD1L1 protein, which plays a key role in cell cycle regulation and chromosome segregation. This antibody, generated in rabbits, is highly specific for human samples and is validated for use in Western blot applications. By binding to the MAD1L1 protein, this antibody allows for the detection and analysis of MAD1L1 in various cell types, making it a critical asset in studies related to cell division, cancer research, and genetic disorders.MAD1L1 is a crucial component of the mitotic spindle assembly checkpoint, ensuring the accurate segregation of chromosomes during cell division.
Dysregulation of MAD1L1 has been implicated in various human diseases, including cancer and developmental disorders. Therefore, understanding the function of MAD1L1 is essential for developing targeted therapies and diagnostic tools for these conditions.By utilizing the MAD1L1 Polyclonal Antibody in your research, you can gain valuable insights into the role of MAD1L1 in cellular processes and disease pathways. This antibody is a reliable tool for immunology and oncology research, providing researchers with the means to investigate the mechanisms underlying chromosome stability and mitotic checkpoint control.
Product Name:
MAD1L1 Polyclonal Antibody
SKU:
CAB24666
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human MAD1L1(NP_003541.2).
MAD1L1 is a component of the mitotic spindle-assembly checkpoint that prevents the onset of anaphase until all chromosome are properly aligned at the metaphase plate. MAD1L1 functions as a homodimer and interacts with MAD2L1. MAD1L1 may play a role in cell cycle control and tumor suppression. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
8379
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of lysates from Rat thymus, using MAD1L1 Rabbit pAb (CAB24666) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
