The MAD1L1 Polyclonal Antibody (CAB1153) is a valuable tool for researchers studying MAD1L1, a key protein involved in cell cycle regulation and mitotic checkpoint control. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the MAD1L1 protein, the antibody enables precise detection and analysis in various cell types, making it an essential component for studies in molecular biology and cancer research.MAD1L1, also known as mitotic spindle assembly checkpoint protein MAD1, plays a crucial role in ensuring proper chromosome segregation during cell division.
Dysregulation of MAD1L1 has been implicated in various human cancers and genetic disorders. Understanding the function and regulation of MAD1L1 is essential for unraveling the mechanisms underlying tumorigenesis and identifying potential therapeutic targets for cancer treatment.By using the MAD1L1 Polyclonal Antibody (CAB1153), researchers can delve deeper into the intricate processes of cell division and mitotic checkpoint control, advancing our knowledge of disease mechanisms and potentially paving the way for the development of novel therapeutic strategies.
Product Name:
MAD1/MAD1L1 Rabbit Polyclonal Antibody
SKU:
CAB1153
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 360-700 of human MAD1/MAD1/MAD1L1 (NP_001013859.1).
MAD1L1 is a component of the mitotic spindle-assembly checkpoint that prevents the onset of anaphase until all chromosome are properly aligned at the metaphase plate. MAD1L1 functions as a homodimer and interacts with MAD2L1. MAD1L1 may play a role in cell cycle control and tumor suppression. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
8379
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using MAD1/MAD1/MAD1L1 antibody (CAB1153) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).
