CD68 Rabbit Polyclonal Antibody (CAB6554)
- SKU:
- CAB6554
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
Product Name: | CD68 Rabbit Polyclonal Antibody |
SKU: | CAB6554 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 100-200 of human CD68 (NP_001242.2). |
Sequence: | TSQG PSTA THSP ATTS HGNA TVHP TSNS TATS PGFT SSAH PEPP PPSP SPSP TSKE TIGD YTWT NGSQ PCVH LQAQ IQIR VMYT TQGG GEAW GISV LNPN K |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IF/ICC,1:50 - 1:200 |
Synonyms: | GP110; LAMP4; SCARD1; CD68 |
Positive Sample: | THP-1,U-937,RAW264.7,Mouse liver,Rat liver,Rat lung |
Conjugate: | Unconjugated |
Cellular Localization: | Cell membrane, Endosome membrane, Lysosome membrane, Single-pass type I membrane protein, Single-pass type I membrane protein. |
Calculated MW: | 37kDa |
Observed MW: | 80-130kDa |
This gene encodes a 110-kD transmembrane glycoprotein that is highly expressed by human monocytes and tissue macrophages. It is a member of the lysosomal/endosomal-associated membrane glycoprotein (LAMP) family. The protein primarily localizes to lysosomes and endosomes with a smaller fraction circulating to the cell surface. It is a type I integral membrane protein with a heavily glycosylated extracellular domain and binds to tissue- and organ-specific lectins or selectins. The protein is also a member of the scavenger receptor family. Scavenger receptors typically function to clear cellular debris, promote phagocytosis, and mediate the recruitment and activation of macrophages. Alternative splicing results in multiple transcripts encoding different isoforms.
Purification Method: | Affinity purification |
Gene ID: | 968 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3. |