The MACC1 Polyclonal Antibody (PAC019964) is a valuable tool for researchers studying the role of MACC1, a transcriptional factor associated with cancer metastasis and progression. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the MACC1 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it an essential reagent for studies in oncology and metastasis research.MACC1, also known as metastasis-associated in colon cancer 1, is a key player in promoting cancer cell migration and invasion, making it a promising target for therapeutic intervention in cancer treatment.
Its involvement in metastatic processes and tumor progression highlights its potential as a biomarker for cancer prognosis and as a target for drug development. By understanding the mechanisms by which MACC1 contributes to cancer metastasis, researchers can pave the way for the development of targeted therapies that inhibit or disrupt these processes, ultimately improving outcomes for cancer patients.
Antibody Name:
MACC1 Antibody (PACO19964)
Antibody SKU:
PACO19964
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:25-1:100
Species Reactivity:
Human
Immunogen:
Synthetic peptide of human MACC1
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO19964(MACC1 Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
MACC1 is a key regulator of the hepatocyte growth factor (HGF; MIM 142409)-HGF receptor (HGFR, or MET; MIM 164860) pathway, which is involved in cellular growth, epithelial-mesenchymal transition, angiogenesis, cell motility, invasiveness, and metastasis. Expression of MACC1 in colon cancer (MIM 114500) specimens is an independent prognostic indicator for metastasis formation and metastasis-free survival
Synonyms:
metastasis associated in colon cancer 1
UniProt Protein Function:
MACC1: Acts as a transcription activator for MET and as a key regulator of HGF-MET signaling. Promotes cell motility, proliferation and hepatocyte growth factor (HGF)-dependent scattering in vitro and tumor growth and metastasis in vivo.
UniProt Protein Details:
Chromosomal Location of Human Ortholog: 7p21.1
Cellular Component: cytoplasm; nucleus
Molecular Function:growth factor activity
Biological Process: regulation of transcription, DNA-dependent; transcription, DNA-dependent; positive regulation of cell division
NCBI Summary:
MACC1 is a key regulator of the hepatocyte growth factor (HGF; MIM 142409)-HGF receptor (HGFR, or MET; MIM 164860) pathway, which is involved in cellular growth, epithelial-mesenchymal transition, angiogenesis, cell motility, invasiveness, and metastasis. Expression of MACC1 in colon cancer (MIM 114500) specimens is an independent prognostic indicator for metastasis formation and metastasis-free survival (Stein et al., 2009 [PubMed 19098908]).[supplied by OMIM, Mar 2009]
