The MACC1 Polyclonal Antibody (PAC019963) is a valuable tool for researchers studying the role of MACC1, a key regulator of tumor growth and metastasis. This antibody, developed in rabbits, exhibits high specificity and sensitivity towards human samples, making it suitable for use in various research applications, including Western blot analysis.MACC1, also known as metastasis-associated in colon cancer 1, is a protein that has been linked to the progression of various cancers, including colon cancer, lung cancer, and gastric cancer. By targeting MACC1, researchers can gain insights into the molecular mechanisms driving cancer metastasis and potentially identify new targets for therapy development.
Furthermore, MACC1 has been implicated in promoting tumor invasion and migration, making it a promising biomarker for predicting cancer prognosis and assessing treatment outcomes. The MACC1 Polyclonal Antibody offers researchers a reliable tool for studying the expression and function of MACC1 in cancer cells, ultimately advancing our understanding of tumor biology and the development of targeted cancer therapies.
Antibody Name:
MACC1 Antibody (PACO19963)
Antibody SKU:
PACO19963
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:25-1:100
Species Reactivity:
Human
Immunogen:
Synthetic peptide of human MACC1
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO19963(MACC1 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
MACC1 is a key regulator of the hepatocyte growth factor (HGF; MIM 142409)-HGF receptor (HGFR, or MET; MIM 164860) pathway, which is involved in cellular growth, epithelial-mesenchymal transition, angiogenesis, cell motility, invasiveness, and metastasis. Expression of MACC1 in colon cancer (MIM 114500) specimens is an independent prognostic indicator for metastasis formation and metastasis-free survival
Synonyms:
metastasis associated in colon cancer 1
UniProt Protein Function:
MACC1: Acts as a transcription activator for MET and as a key regulator of HGF-MET signaling. Promotes cell motility, proliferation and hepatocyte growth factor (HGF)-dependent scattering in vitro and tumor growth and metastasis in vivo.
UniProt Protein Details:
Chromosomal Location of Human Ortholog: 7p21.1
Cellular Component: cytoplasm; nucleus
Molecular Function:growth factor activity
Biological Process: regulation of transcription, DNA-dependent; transcription, DNA-dependent; positive regulation of cell division
NCBI Summary:
MACC1 is a key regulator of the hepatocyte growth factor (HGF; MIM 142409)-HGF receptor (HGFR, or MET; MIM 164860) pathway, which is involved in cellular growth, epithelial-mesenchymal transition, angiogenesis, cell motility, invasiveness, and metastasis. Expression of MACC1 in colon cancer (MIM 114500) specimens is an independent prognostic indicator for metastasis formation and metastasis-free survival (Stein et al., 2009 [PubMed 19098908]).[supplied by OMIM, Mar 2009]
