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MACC1 Antibody (PACO07500)

SKU:
PACO07500
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
IHC
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€459
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Description

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MACC1 Antibody (PACO07500)

The MACC1 Polyclonal Antibody (PACO07500) is a valuable tool for researchers studying the role of MACC1 in cancer progression and metastasis. This antibody, raised in rabbits, is highly specific to human samples and has been validated for use in various applications, including Western blotting.MACC1, also known as metastasis-associated in colon cancer 1, is a key regulator of cancer metastasis and has been implicated in the progression of various types of cancer. By targeting MACC1 with this antibody, researchers can investigate its role in cancer development and potentially identify new therapeutic targets for inhibiting metastasis.

With its high reactivity and specificity, the MACC1 Polyclonal Antibody is an essential tool for studies in cancer biology and may contribute to the development of novel treatments for metastatic cancer. Its ability to detect MACC1 protein in different cell types makes it an ideal choice for researchers in the fields of oncology and cancer research.

Antibody Name:MACC1 Antibody (PACO07500)
Antibody SKU:PACO07500
Size:50ul
Host Species:Rabbit
Tested Applications:ELISA, IHC
Recommended Dilutions:
Species Reactivity:Human
Immunogen:Recombinant Human Metastasis-associated in colon cancer protein 1 protein
Form:Liquid
Storage Buffer:PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Purification Method:Antigen Affinity purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Background:Acts as a transcription activator for MET and as a key regulator of HGF-MET signaling. Promotes cell motility, proliferation and hepatocyte growth factor (HGF)-dependent scattering in vitro and tumor growth and metastasis in vivo.
Synonyms:SH3 domain-containing protein 7a5,MACC1
UniProt Protein Function:MACC1: Acts as a transcription activator for MET and as a key regulator of HGF-MET signaling. Promotes cell motility, proliferation and hepatocyte growth factor (HGF)-dependent scattering in vitro and tumor growth and metastasis in vivo.
UniProt Protein Details:

Chromosomal Location of Human Ortholog: 7p21.1

Cellular Component: cytoplasm; nucleus

Molecular Function:growth factor activity

Biological Process: regulation of transcription, DNA-dependent; transcription, DNA-dependent; positive regulation of cell division

NCBI Summary:MACC1 is a key regulator of the hepatocyte growth factor (HGF; MIM 142409)-HGF receptor (HGFR, or MET; MIM 164860) pathway, which is involved in cellular growth, epithelial-mesenchymal transition, angiogenesis, cell motility, invasiveness, and metastasis. Expression of MACC1 in colon cancer (MIM 114500) specimens is an independent prognostic indicator for metastasis formation and metastasis-free survival (Stein et al., 2009 [PubMed 19098908]).[supplied by OMIM, Mar 2009]
UniProt Code:Q6ZN28
NCBI GenInfo Identifier:157502191
NCBI Gene ID:346389
NCBI Accession:NP_877439.3
UniProt Secondary Accession:Q6ZN28,Q6ZQN8, Q7Z5A5, A8MUS5, B2RNR9,
UniProt Related Accession:Q6ZN28
Molecular Weight:96,639 Da
NCBI Full Name:metastasis-associated in colon cancer protein 1
NCBI Synonym Full Names:metastasis associated in colon cancer 1
NCBI Official Symbol:MACC1  
NCBI Official Synonym Symbols:7A5; SH3BP4L  
NCBI Protein Information:metastasis-associated in colon cancer protein 1; putative binding protein 7a5; SH3 domain-containing protein 7a5
UniProt Protein Name:Metastasis-associated in colon cancer protein 1
UniProt Synonym Protein Names:SH3 domain-containing protein 7a5
Protein Family:Metastasis-associated in colon cancer protein
UniProt Gene Name:MACC1  
UniProt Entry Name:MACC1_HUMAN

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