null

MACC1 Antibody (PACO01992)

SKU:
PACO01992
Product Type:
Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€269

Description

system_update_altDatasheetsystem_update_altMSDS

MACC1 Antibody (PACO01992)

The MACC1 Polyclonal Antibody (PACO01992) is a valuable tool for researchers studying the metastasis-associated in colon cancer 1 (MACC1) protein. This antibody, produced in rabbits, is highly specific for detecting MACC1 in human samples and is validated for use in Western blot applications. By targeting the MACC1 protein, researchers can analyze its expression levels and activity in various cell types, providing insights into its role in cancer progression and metastasis.

MACC1 is a key player in promoting tumor growth, invasion, and metastasis in colon cancer and other solid tumors. By understanding the function of MACC1, researchers can uncover new therapeutic targets and strategies for combating metastatic disease. The MACC1 Polyclonal Antibody is an essential tool for investigating the molecular mechanisms underlying tumor metastasis and developing targeted therapies for cancer patients.

Antibody Name:MACC1 Antibody
Antibody SKU:PACO01992
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, WB
Recommended Dilutions:WB:1:500-1:2000
Species Reactivity:Human, Mouse
Immunogen:synthesized peptide derived from the Internal region of human MACC1.
Form:Liquid
Storage Buffer:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:MACC1; Metastasis-associated in colon cancer protein 1; SH3 domain-containing protein 7a5
UniProt Protein Function:MACC1: Acts as a transcription activator for MET and as a key regulator of HGF-MET signaling. Promotes cell motility, proliferation and hepatocyte growth factor (HGF)-dependent scattering in vitro and tumor growth and metastasis in vivo.
UniProt Protein Details:

Chromosomal Location of Human Ortholog: 7p21.1

Cellular Component: cytoplasm; nucleus

Molecular Function:growth factor activity

Biological Process: regulation of transcription, DNA-dependent; transcription, DNA-dependent; positive regulation of cell division

NCBI Summary:MACC1 is a key regulator of the hepatocyte growth factor (HGF; MIM 142409)-HGF receptor (HGFR, or MET; MIM 164860) pathway, which is involved in cellular growth, epithelial-mesenchymal transition, angiogenesis, cell motility, invasiveness, and metastasis. Expression of MACC1 in colon cancer (MIM 114500) specimens is an independent prognostic indicator for metastasis formation and metastasis-free survival (Stein et al., 2009 [PubMed 19098908]).[supplied by OMIM, Mar 2009]
UniProt Code:Q6ZN28
NCBI GenInfo Identifier:157502191
NCBI Gene ID:346389
NCBI Accession:NP_877439.3
UniProt Secondary Accession:Q6ZN28,Q6ZQN8, Q7Z5A5, A8MUS5, B2RNR9,
UniProt Related Accession:Q6ZN28
Molecular Weight:96,639 Da
NCBI Full Name:metastasis-associated in colon cancer protein 1
NCBI Synonym Full Names:metastasis associated in colon cancer 1
NCBI Official Symbol:MACC1  
NCBI Official Synonym Symbols:7A5; SH3BP4L  
NCBI Protein Information:metastasis-associated in colon cancer protein 1; putative binding protein 7a5; SH3 domain-containing protein 7a5
UniProt Protein Name:Metastasis-associated in colon cancer protein 1
UniProt Synonym Protein Names:SH3 domain-containing protein 7a5
Protein Family:Metastasis-associated in colon cancer protein
UniProt Gene Name:MACC1  
UniProt Entry Name:MACC1_HUMAN

Related Products