Description
MACC1 Antibody (PACO01992)
The MACC1 Polyclonal Antibody (PACO01992) is a valuable tool for researchers studying the metastasis-associated in colon cancer 1 (MACC1) protein. This antibody, produced in rabbits, is highly specific for detecting MACC1 in human samples and is validated for use in Western blot applications. By targeting the MACC1 protein, researchers can analyze its expression levels and activity in various cell types, providing insights into its role in cancer progression and metastasis.
MACC1 is a key player in promoting tumor growth, invasion, and metastasis in colon cancer and other solid tumors. By understanding the function of MACC1, researchers can uncover new therapeutic targets and strategies for combating metastatic disease. The MACC1 Polyclonal Antibody is an essential tool for investigating the molecular mechanisms underlying tumor metastasis and developing targeted therapies for cancer patients.
Antibody Name: | MACC1 Antibody |
Antibody SKU: | PACO01992 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB |
Recommended Dilutions: | WB:1:500-1:2000 |
Species Reactivity: | Human, Mouse |
Immunogen: | synthesized peptide derived from the Internal region of human MACC1. |
Form: | Liquid |
Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Synonyms: | MACC1; Metastasis-associated in colon cancer protein 1; SH3 domain-containing protein 7a5 |
UniProt Protein Function: | MACC1: Acts as a transcription activator for MET and as a key regulator of HGF-MET signaling. Promotes cell motility, proliferation and hepatocyte growth factor (HGF)-dependent scattering in vitro and tumor growth and metastasis in vivo. |
UniProt Protein Details: | Chromosomal Location of Human Ortholog: 7p21.1 Cellular Component: cytoplasm; nucleus Molecular Function:growth factor activity Biological Process: regulation of transcription, DNA-dependent; transcription, DNA-dependent; positive regulation of cell division |
NCBI Summary: | MACC1 is a key regulator of the hepatocyte growth factor (HGF; MIM 142409)-HGF receptor (HGFR, or MET; MIM 164860) pathway, which is involved in cellular growth, epithelial-mesenchymal transition, angiogenesis, cell motility, invasiveness, and metastasis. Expression of MACC1 in colon cancer (MIM 114500) specimens is an independent prognostic indicator for metastasis formation and metastasis-free survival (Stein et al., 2009 [PubMed 19098908]).[supplied by OMIM, Mar 2009] |
UniProt Code: | Q6ZN28 |
NCBI GenInfo Identifier: | 157502191 |
NCBI Gene ID: | 346389 |
NCBI Accession: | NP_877439.3 |
UniProt Secondary Accession: | Q6ZN28,Q6ZQN8, Q7Z5A5, A8MUS5, B2RNR9, |
UniProt Related Accession: | Q6ZN28 |
Molecular Weight: | 96,639 Da |
NCBI Full Name: | metastasis-associated in colon cancer protein 1 |
NCBI Synonym Full Names: | metastasis associated in colon cancer 1 |
NCBI Official Symbol: | MACC1Â Â |
NCBI Official Synonym Symbols: | 7A5; SH3BP4LÂ Â |
NCBI Protein Information: | metastasis-associated in colon cancer protein 1; putative binding protein 7a5; SH3 domain-containing protein 7a5 |
UniProt Protein Name: | Metastasis-associated in colon cancer protein 1 |
UniProt Synonym Protein Names: | SH3 domain-containing protein 7a5 |
Protein Family: | Metastasis-associated in colon cancer protein |
UniProt Gene Name: | MACC1Â Â |
UniProt Entry Name: | MACC1_HUMAN |