The M6PR Rabbit Monoclonal Antibody (CAB3762) is a cutting-edge tool for researchers studying the Mannose 6-Phosphate Receptor (M6PR) protein. This antibody, produced from rabbit cells, exhibits high specificity and sensitivity in detecting M6PR in human samples, making it a reliable choice for Western blot applications.The M6PR protein plays a crucial role in cellular processes such as lysosomal enzyme trafficking and autophagy, making it a key player in maintaining cellular homeostasis. Dysregulation of M6PR has been implicated in various diseases, including lysosomal storage disorders and cancer.
By using this antibody to target and analyze M6PR expression, researchers can gain valuable insights into the mechanisms underlying these diseases and potentially identify novel therapeutic targets for intervention.With its proven performance in detecting M6PR in a variety of cell types, the M6PR Rabbit Monoclonal Antibody (CAB3762) is an indispensable tool for investigations in cell biology, molecular biology, and disease pathology. Don't miss out on the opportunity to enhance your research with this powerful antibody.
Lysosome membrane, Single-pass type I membrane protein.
Calculated MW:
274kDa
Observed MW:
274kDa
This gene encodes a receptor for both insulin-like growth factor 2 and mannose 6-phosphate. The binding sites for each ligand are located on different segments of the protein. This receptor has various functions, including in the intracellular trafficking of lysosomal enzymes, the activation of transforming growth factor beta, and the degradation of insulin-like growth factor 2. Mutation or loss of heterozygosity of this gene has been association with risk of hepatocellular carcinoma. The orthologous mouse gene is imprinted and shows exclusive expression from the maternal allele; however, imprinting of the human gene may be polymorphic, as only a minority of individuals showed biased expression from the maternal allele (PMID:8267611).
Purification Method:
Affinity purification
Gene ID:
3482
Clone Number:
ARC0263
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of A-549 cells, using Cation-independent Cation-independent M6PR (IGF2R) (IGF2R) Rabbit mAb (CAB3762) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
