Cation-independent M6PR (IGF2R) Rabbit Monoclonal Antibody (CAB3762)
- SKU:
- CAB3762
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Signal Transduction
Frequently bought together:
Description
Product Name: | Cation-independent M6PR (IGF2R) Rabbit Monoclonal Antibody |
SKU: | CAB3762 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 2392-2491 of human Cation-independent M6PR (IGF2R) (NP_000867.3). |
Sequence: | TTKS VKAL SSLH GDDQ DSED EVLT IPEV KVHS GRGA GAES SHPV RNAQ SNAL QERE DDRV GLVR GEKA RKGK SSSA QQKT VSST KLVS FHDD SDED LLHI |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IF/ICC,1:50 - 1:200 |
Synonyms: | MPR1; MPRI; CD222; CIMPR; M6P-R; MPR300; CI-M6PR; MPR 300; M6P/IGF2R; Cation-independent M6PR (IGF2R) |
Positive Sample: | A-549,Mouse heart |
Conjugate: | Unconjugated |
Cellular Localization: | Lysosome membrane, Single-pass type I membrane protein. |
Calculated MW: | 274kDa |
Observed MW: | 274kDa |
This gene encodes a receptor for both insulin-like growth factor 2 and mannose 6-phosphate. The binding sites for each ligand are located on different segments of the protein. This receptor has various functions, including in the intracellular trafficking of lysosomal enzymes, the activation of transforming growth factor beta, and the degradation of insulin-like growth factor 2. Mutation or loss of heterozygosity of this gene has been association with risk of hepatocellular carcinoma. The orthologous mouse gene is imprinted and shows exclusive expression from the maternal allele; however, imprinting of the human gene may be polymorphic, as only a minority of individuals showed biased expression from the maternal allele (PMID:8267611).
Purification Method: | Affinity purification |
Gene ID: | 3482 |
Clone Number: | ARC0263 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3. |