The M6PR Polyclonal Antibody is a valuable tool for research involving the M6PR protein, a critical component involved in the transport of lysosomal enzymes. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By targeting the M6PR protein, researchers can study its role in various cellular processes, making it ideal for studies in cell biology and lysosomal storage disorders.The M6PR protein is essential for targeting lysosomal enzymes to the lysosome, ensuring proper degradation of cellular waste and maintenance of cellular homeostasis. Mutations in the M6PR gene have been linked to lysosomal storage disorders, highlighting the importance of understanding its function in health and disease.
Research with the M6PR antibody can provide valuable insights into lysosomal biology and potential therapeutic targets for lysosomal storage disorders.Overall, the M6PR Polyclonal Antibody is a crucial tool for researchers studying lysosomal biology and related disorders, offering specific detection and analysis of the M6PR protein in various cell types. Its use can advance our understanding of lysosomal function and provide new insights into the development of treatments for lysosomal storage disorders.
Product Name:
M6PR Polyclonal Antibody
SKU:
CAB21486
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 27-185 of human M6PR (NP_002346.1).
Lysosome membrane, Single-pass type I membrane protein.
Calculated MW:
31kDa
Observed MW:
Refer to figures
This gene encodes a member of the P-type lectin family. P-type lectins play a critical role in lysosome function through the specific transport of mannose-6-phosphate-containing acid hydrolases from the Golgi complex to lysosomes. The encoded protein functions as a homodimer and requires divalent cations for ligand binding. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome X.
Purification Method:
Affinity purification
Gene ID:
4074
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of lysates from mouse kidney, using M6PR Rabbit pAb (CAB21486) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 40s.
