LZTS2 Rabbit Polyclonal Antibody (CAB14598)
- SKU:
- CAB14598
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Cycle
Frequently bought together:
Description
Product Name: | LZTS2 Rabbit Polyclonal Antibody |
SKU: | CAB14598 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 470-669 of human LZTS2 (NP_115805.1). |
Sequence: | ELVA LRVA LREA RATL RVSE GRAR GLQE AARA RELE LEAC SQEL QRHR QEAE QLRE KAGQ LDAE AAGL REPP VPPA TADP FLLA ESDE AKVQ RAAA GVGG SLRA QVER LRVE LQRE RRRG EEQR DSFE GERL AWQA EKEQ VIRY QKQL QHNY IQMY RRNR QLEQ ELQQ LSLE LEAR ELAD LGLA EQAP CICL EEIT ATEI |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | LAPSER1; LZTS2 |
Positive Sample: | DU145,HT-29,HeLa,U-87MG,MCF7,Mouse brain,Rat kidney,Rat brain |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, centrosome, cytoskeleton, microtubule organizing center. |
Calculated MW: | 73kDa |
Observed MW: | 73kDa |
The protein encoded by this gene belongs to the leucine zipper tumor suppressor family of proteins, which function in transcription regulation and cell cycle control. This family member can repress beta-catenin-mediated transcriptional activation and is a negative regulator of the Wnt signaling pathway. It negatively regulates microtubule severing at centrosomes, and is necessary for central spindle formation and cytokinesis completion. It is implicated in cancer, where it may inhibit cell proliferation and decrease susceptibility to tumor development. Alternative splicing of this gene results in multiple transcript variants.
Purification Method: | Affinity purification |
Gene ID: | 84445 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |