The LZTS1 Polyclonal Antibody (CAB16496) is a valuable tool for researchers studying the LZTS1 protein, involved in cell cycle regulation and tumor suppression. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the LZTS1 protein, researchers can detect and analyze its expression in various cell types, making it an ideal choice for studies in cancer research and cell biology.LZTS1 plays a crucial role in maintaining genomic stability and preventing aberrant cell division, making it a promising target for cancer therapy research.
Understanding the function of LZTS1 can provide valuable insights into the mechanisms of tumor development and progression, paving the way for the development of novel therapeutic strategies targeting this protein. The use of the LZTS1 Polyclonal Antibody is essential for accurate and reliable detection of LZTS1 protein levels, contributing to advancements in cancer research and drug discovery.
Product Name:
LZTS1 Rabbit Polyclonal Antibody
SKU:
CAB16496
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 337-596 of human LZTS1 (NP_066300.1).
This gene encodes a tumor suppressor protein that is ubiquitously expressed in normal tissues. In uveal melanomas, expression of this protein is silenced in rapidly metastasizing and metastatic tumor cells but has normal expression in slowly metastasizing or nonmetastasizing tumor cells. This protein may have a role in cell-cycle control by interacting with the Cdk1/cyclinB1 complex. This gene is located on chromosomal region 8p22. Loss of heterozygosity (LOH) in the 8p arm is a common characteristic of many types of cancer.
Purification Method:
Affinity purification
Gene ID:
11178
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from Rat brain, using LZTS1 Rabbit pAb (CAB16496) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 90s.
