The LZTFL1 Polyclonal Antibody (PACO10323) is a valuable tool for researchers studying LZTFL1, a protein involved in the regulation of ciliary trafficking and signaling pathways. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding to the LZTFL1 protein, this antibody allows for accurate detection and analysis in a variety of cell types, making it an essential component for studies in cell biology and molecular biology.LZTFL1 plays a crucial role in the proper functioning of cilia, which are hair-like structures found on the surface of cells and play a key role in cellular signaling and communication.
Dysfunction of cilia has been implicated in a range of diseases, including ciliopathies and cancer. By investigating the function of LZTFL1, researchers can gain valuable insights into the mechanisms underlying these disorders and potentially identify new targets for therapeutic intervention. The availability of a reliable antibody like PACO10323 is essential for advancing our understanding of LZTFL1 and its role in human health and disease.
LZTFL1: Belongs to the LZTFL1 family.Chromosomal Location of Human Ortholog: 3p21.3Cellular Component: cytosolMolecular Function: identical protein binding; protein binding; protein complex bindingDisease: Bardet-biedl Syndrome 17
UniProt Protein Details:
NCBI Summary:
This gene encodes a ubiquitously expressed protein that localizes to the cytoplasm. This protein interacts with Bardet-Biedl Syndrome (BBS) proteins and, through its interaction with BBS protein complexes, regulates protein trafficking to the ciliary membrane. Nonsense mutations in this gene cause a form of Bardet-Biedl Syndrome; a ciliopathy characterized in part by polydactyly, obesity, cognitive impairment, hypogonadism, and kidney failure. This gene may also function as a tumor suppressor; possibly by interacting with E-cadherin and the actin cytoskeleton and thereby regulating the transition of epithelial cells to mesenchymal cells. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2013]
