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LYVE1 Monoclonal Antibody [P4G1AT] (CPAB0128)

SKU:
CPAB0128
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Mouse
Isotype:
IgG2b
Clone:
P4G1AT
Applications:
WB
ELISA
€149
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Description

system_update_alt Datasheet

LYVE1 Monoclonal Antibody [P4G1AT] (CPAB0128)

The LYVE1 Polyclonal Antibody (CPAB0128) is a valuable tool for researchers studying LYVE1, a cell surface receptor known to be involved in lymphatic vessel development and function. This antibody, produced in rabbits, is highly specific for human samples and has been validated for use in various applications, including Western blot and immunohistochemistry.LYVE1 is a key player in the regulation of lymphatic endothelial cell function, serving as a receptor for hyaluronan and playing a role in the clearance of hyaluronan from the lymphatic system. Dysregulation of LYVE1 has been implicated in various diseases, including cancer and inflammatory disorders, making it a promising target for therapeutic intervention.

With its high reactivity and specificity for human samples, the LYVE1 Polyclonal Antibody is an essential tool for researchers looking to explore the role of LYVE1 in health and disease. Its ability to detect and analyze LYVE1 protein in different cell types makes it an invaluable asset for studies in lymphatic biology and related fields. Unlock the potential of LYVE1 research with this high-quality antibody.

Product Name:LYVE1 Antibody
Product Sku:CPAB0128
Size:5μg
Host Species:Mouse
Immunogen:Anti-human LYVE1 mAb is derived from hybridization of mouse SP2/O myeloma cells with spleen cells from BALB/c mice immunized with recombinant human LYVE1 amino acids 25-235 purified from Ecoli.
Clone:P4G1AT.
Reactivity:Human
Applications:Western Blot, ELISA
Purification Method:LYVE1 antibody was purified from mouse ascitic fluids by protein-G affinity chromatography.
Isotype:IgG2b
Background:LYVE-1 has been identified as a major receptor for HA (extracellular matrix glycosaminoglycan hyaluronan) on the lymph vessel wall. The deduced amino acid sequence of LYVE-1 predicts a 322-residue type I integral membrane polypeptide 41% similar to the CD44 HA receptor with a 212-residue extracellular domain containing a single Link module the prototypic HA binding domain of the Link protein superfamily. Like CD44, the LYVE-1 molecule binds both soluble and immobilized HA. However, unlike CD44, the LYVE-1 molecule colocalizes with HA on the luminal face of the lymph vessel wall and is completely absent from blood vessels. Hence, LYVE-1 is the first lymph-specific HA receptor to be characterized and is a uniquely powerful marker for lymph vessels themselves.
Synonyms:Lymphatic vessel endothelial hyaluronic acid receptor 1 precursor, LYVE-1, Cell surface retention sequence-binding protein 1, CRSBP-1, Hyaluronic acid receptor, Extracellular link domain-containing protein.
Storage Buffer:For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C. Prevent freeze thaw cycles.

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