The LYPLA1 Polyclonal Antibody (CAB4419) is a valuable tool for researchers studying LYPLA1, a phospholipase enzyme involved in lipid metabolism and cellular signaling pathways. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the LYPLA1 protein, researchers can accurately detect and analyze its expression in a variety of cell types, making it an excellent choice for studies in biochemistry, metabolism, and cell signaling.
LYPLA1 plays a crucial role in lipid metabolism by hydrolyzing lysophospholipids, which are important components of cell membranes and signaling molecules. Dysregulation of LYPLA1 activity has been implicated in various diseases, including metabolic disorders, neurodegenerative diseases, and cancer. Understanding the function and regulation of LYPLA1 is key to unraveling its role in these conditions and developing targeted therapies to modulate lipid metabolism and cellular signaling pathways.
Product Name:
LYPLA1 Rabbit Polyclonal Antibody
SKU:
CAB4419
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-230 of human LYPLA1 (NP_006321.1).
This gene encodes a member of the alpha/beta hydrolase superfamily. The encoded protein functions as a homodimer, exhibiting both depalmitoylating as well as lysophospholipase activity, and may be involved in Ras localization and signaling. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene have been defined on chromosomes 4, 6, and 7.
Purification Method:
Affinity purification
Gene ID:
10434
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using LYPLA1 Rabbit pAb (CAB4419) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates / proteins: 25 μg per lane.Blocking buffer: 3 % nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
