The LYL1 Polyclonal Antibody (PACO04257) offered by Assay Genie is a valuable tool for researchers studying the LYL1 protein, a transcription factor crucial for hematopoiesis and leukemogenesis. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in various applications including Western blot and immunohistochemistry.LYL1, also known as lymphoblastic leukemia-derived sequence 1, plays a pivotal role in regulating the development and function of blood cells. Dysregulation of LYL1 has been associated with leukemia and other hematologic disorders, making it a promising target for therapeutic interventions.
By utilizing the LYL1 antibody, researchers can detect and analyze LYL1 expression in different cell types, contributing to a better understanding of its role in normal hematopoiesis and disease pathogenesis.Furthermore, the LYL1 antibody from Assay Genie provides a reliable tool for investigating the mechanisms underlying LYL1-mediated cellular processes, making it a valuable asset for studies in hematology, oncology, and stem cell research. By elucidating the functions of LYL1, researchers can potentially uncover new therapeutic strategies for treating blood-related disorders.
Antibody Name:
LYL1 Antibody
Antibody SKU:
PACO04257
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
IHC:1:100-1:300
Species Reactivity:
Human, Mouse, Rat
Immunogen:
synthesized peptide derived from the Internal region of human Lyl-1.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
LYL1; BHLHA18; Protein lyl-1; Class A basic helix-loop-helix protein 18; bHLHa18; Lymphoblastic leukemia-derived sequence 1
UniProt Protein Function:
LYL1: A chromosomal aberration involving LYL1 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(7;19)(q35;p13) with TCRB.Protein type: Transcription factor; DNA-binding; OncoproteinChromosomal Location of Human Ortholog: 19p13.2Cellular Component: nucleusMolecular Function: DNA binding; protein bindingBiological Process: B cell differentiation; blood vessel maturation; positive regulation of transcription, DNA-dependent; regulation of transcription, DNA-dependent
UniProt Protein Details:
NCBI Summary:
This gene represents a basic helix-loop-helix transcription factor. The encoded protein may play roles in blood vessel maturation and hematopoeisis. A translocation between this locus and the T cell receptor beta locus (GeneID 6957) on chromosome 7 has been associated with acute lymphoblastic leukemia. [provided by RefSeq, Sep 2010]
