LXRα Rabbit Monoclonal Antibody (CAB3974)
- SKU:
- CAB3974
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
Product Name: | LXRα Rabbit Monoclonal Antibody |
SKU: | CAB3974 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human LXRα (Q13133). |
Sequence: | MSLW LGAP VPDI PPDS AVEL WKPG AQDA SSQA QGGS SCIL REEA RMPH SAGG TAGV GLEA AEPT ALLT RAEP PSEP TEIR PQKR KKGP APKM LGNE LCSV |
Tested Applications: | WB IHC-P IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:200 |
Synonyms: | LXRA; LXR-a; RLD-1; LXRα |
Positive Sample: | 293T,HepG2,Mouse liver,Mouse kidney,Mouse stomach,Rat liver |
Conjugate: | Unconjugated |
Cellular Localization: | Nucleus. |
Calculated MW: | 50kDa |
Observed MW: | 50kDa |
The protein encoded by this gene belongs to the NR1 subfamily of the nuclear receptor superfamily. The NR1 family members are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. This protein is highly expressed in visceral organs, including liver, kidney and intestine. It forms a heterodimer with retinoid X receptor (RXR), and regulates expression of target genes containing retinoid response elements. Studies in mice lacking this gene suggest that it may play an important role in the regulation of cholesterol homeostasis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Purification Method: | Affinity purification |
Gene ID: | 10062 |
Clone Number: | ARC0877 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3. |