The LXRalpha Rabbit Monoclonal Antibody (CAB3974) is a valuable tool for researchers studying the Liver X Receptor alpha (LXRalpha) protein, a key regulator of lipid metabolism and inflammation. This antibody, raised in rabbits, is highly specific for LXRalpha and has been validated for use in various applications, including immunohistochemistry and immunofluorescence.LXRalpha is a nuclear receptor that plays a crucial role in regulating cholesterol metabolism, inflammation, and immune response. Dysregulation of LXRalpha has been associated with various diseases, including atherosclerosis, diabetes, and inflammatory conditions.
By using the LXRalpha Rabbit Monoclonal Antibody, researchers can better understand the function of LXRalpha in these disease processes and potentially discover new therapeutic targets.Whether investigating the role of LXRalpha in lipid homeostasis or its impact on inflammatory signaling pathways, this antibody provides precise and reliable detection of LXRalpha protein in experimental samples. Its high specificity and sensitivity make it an essential tool for studies in metabolic disorders, cardiovascular diseases, and inflammatory conditions.
Product Name:
LXRα Rabbit Monoclonal Antibody
SKU:
CAB3974
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human LXRα (Q13133).
The protein encoded by this gene belongs to the NR1 subfamily of the nuclear receptor superfamily. The NR1 family members are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. This protein is highly expressed in visceral organs, including liver, kidney and intestine. It forms a heterodimer with retinoid X receptor (RXR), and regulates expression of target genes containing retinoid response elements. Studies in mice lacking this gene suggest that it may play an important role in the regulation of cholesterol homeostasis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
10062
Clone Number:
ARC0877
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using LXRα Rabbit mAb (CAB3974) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3s.
