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LXR beta/NER Polyclonal Antibody

SKU:
CAB22545
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
WB
€129 - €359
Frequently bought together:

Description

LXR beta/NER Polyclonal Antibody (CAB22545)

The LXR beta NER Polyclonal Antibody is a valuable tool for researchers studying the Liver X Receptor beta (LXR beta) and its involvement in regulating lipid metabolism and inflammation in various diseases. This antibody, produced in rabbits, is highly specific for human samples and has been validated for use in Western blot applications, allowing for the detection and analysis of LXR beta protein levels in different cell types.LXR beta is a nuclear receptor that plays a crucial role in regulating cholesterol metabolism, lipid homeostasis, and inflammatory responses. Dysregulation of LXR beta has been associated with various metabolic disorders, cardiovascular diseases, and inflammatory conditions, making it a promising target for therapeutic interventions.

By studying the expression and function of LXR beta using this antibody, researchers can gain valuable insights into the mechanisms underlying these diseases and potentially identify novel therapeutic strategies.Overall, the LXR beta NER Polyclonal Antibody is a reliable tool for researchers interested in exploring the role of LXR beta in health and disease, with potential applications in metabolic disorders, cardiovascular diseases, and inflammation-related research.

Product Name:LXR beta/NER Polyclonal Antibody
Product Code:CAB22545
Reactivity:Human, Mouse, Rat
Applications:Western blotting
Host Species:Rabbit
Purification Method:Affinity purification
Isotype:IgG
Reactivity:Human, Mouse, Rat
Tested Applications:WB, ELISA
Key Applications:Western blotting
Recommended Dilution:WB 1:100-1:500
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 50% glycerol, pH7.3.
Positive Samples:HeLa
Cellular Location:cytoplasm, cytosol, nucleoplasm, nucleus

The liver X receptors, LXRA (NR1H3; MIM 602423) and LXRB, form a subfamily of the nuclear receptor superfamily and are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. The inducible LXRA is highly expressed in liver, adrenal gland, intestine, adipose tissue, macrophages, lung, and kidney, whereas LXRB is ubiquitously expressed. Ligand-activated LXRs form obligate heterodimers with retinoid X receptors (RXRs; see MIM 180245) and regulate expression of target genes containing LXR response elements (summary by Korf et al., 2009 [PubMed 19436111]).

Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-100 of human LXR beta/NER. (P55055).
Sequence:MSSPT TSSLD TPLPG NGPPQ PGAPS SSPTV KEEGP EPWPG GPDPD VPGTD EASSA CSTDW VIPDP EEEPE RKRKK GPAPK MLGHE LCRVC GDKAS GFHYN
Synonyms:NER, UNR, LXRB, LXR-b, NER-I, RIP15
Calculated MW:51kDa
Observed MW:51kDa

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