The LXN Antibody (PAC014659) is a critical tool for researchers studying the LXN protein, a member of the ALEX family of proteins that play a role in cell differentiation and proliferation. Raised in rabbits, this polyclonal antibody is highly specific to human samples and has been validated for use in various applications, including Western blotting. The LXN Antibody binds specifically to the LXN protein, allowing for accurate detection and analysis in a variety of cell types. Its role in regulating cell growth and differentiation makes it a valuable target for studies in developmental biology, cancer research, and stem cell research.
By understanding the function and activity of the LXN protein, researchers can gain insights into important cellular processes and potentially discover new therapeutic targets for diseases such as cancer. The LXN Antibody is a valuable tool for advancing research in this field and uncovering the potential of the LXN protein in various biological contexts.
The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO14659(LXN Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: x200).
Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: A549 cells, Primary antibody: PACO14659(LXN Antibody) at dilution 1/667, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds.
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO14659(LXN Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: x200).
Background:
Latexin, also designated endogenous carboxypeptidase inhibitor (ECI) or tissue carboxypeptidase inhibitor (TCI), belongs to the protease inhibitor I47 family of proteins. Latexin acts as a non-competitive, reversible inhibitor for metallocarboxypeptidases (MCPs), including CPA1, CPA2 and CPA4. It is a cytoplasmic protein that is highly expressed in heart, prostate, pancreas, ovary, kidney, brain and colon. Latexin consists of two topologically equivalent subdomains that bind to MCPs with low specificity, which gives it with the flexibility to inhibit all vertebrate A/B MCPs.
Synonyms:
latexin
UniProt Protein Function:
LXN: Hardly reversible, non-competitive, and potent inhibitor of CPA1, CPA2 and CPA4. Belongs to the protease inhibitor I47 (latexin) family.
UniProt Protein Details:
Chromosomal Location of Human Ortholog: 3q25.32
Molecular Function:protein binding
NCBI Summary:
This gene encodes the only known protein inhibitor of zinc-dependent metallocarboxypeptidases. [provided by RefSeq, Oct 2008]
