The LXN Antibody (PAC014658) is a polyclonal antibody developed for research focusing on LXN, a protein associated with various biological functions, including cell differentiation and proliferation. This rabbit-derived antibody is highly reactive with human samples and has been validated for use in Western blot applications. By specifically binding to the LXN protein, this antibody allows for accurate detection and analysis in a variety of cell types, making it an essential tool for researchers in the fields of cell biology and cancer research.
LXN, also known as relaxin, is a multifunctional protein involved in regulating cell growth, differentiation, and apoptosis. Its diverse roles in cellular processes make it a promising target for studies aimed at understanding its impact on tumor development, metastasis, and therapeutic responses in cancer. The LXN Antibody provides researchers with the means to explore the mechanisms underlying LXN function and its potential implications for disease progression and treatment strategies.
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO14658(LXN Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: x200).
Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: A549 cells, Primary antibody: PACO14658(LXN Antibody) at dilution 1/667, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds.
The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using PACO14658(LXN Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: x200).
Background:
Latexin, also designated endogenous carboxypeptidase inhibitor (ECI) or tissue carboxypeptidase inhibitor (TCI), belongs to the protease inhibitor I47 family of proteins. Latexin acts as a non-competitive, reversible inhibitor for metallocarboxypeptidases (MCPs), including CPA1, CPA2 and CPA4. It is a cytoplasmic protein that is highly expressed in heart, prostate, pancreas, ovary, kidney, brain and colon. Latexin consists of two topologically equivalent subdomains that bind to MCPs with low specificity, which gives it with the flexibility to inhibit all vertebrate A/B MCPs.
Synonyms:
latexin
UniProt Protein Function:
LXN: Hardly reversible, non-competitive, and potent inhibitor of CPA1, CPA2 and CPA4. Belongs to the protease inhibitor I47 (latexin) family.
UniProt Protein Details:
Chromosomal Location of Human Ortholog: 3q25.32
Molecular Function:protein binding
NCBI Summary:
This gene encodes the only known protein inhibitor of zinc-dependent metallocarboxypeptidases. [provided by RefSeq, Oct 2008]
