Lum Antibody (PACO48998)
- SKU:
- PACO48998
- Product Type:
- Antibody
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
Lum Antibody (PACO48998)
The LUM Antibody (PAC04898) offered by AssayGenie is a valuable tool for researchers studying the protein LUM, also known as Lumican. Lumican is a small leucine-rich proteoglycan found in the extracellular matrix of various tissues, where it plays a role in collagen fibril assembly and regulation of cell adhesion.This polyclonal antibody, raised in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. By binding to the LUM protein, researchers can detect and analyze its expression in different cell types, making it an ideal tool for studies in connective tissue disorders, wound healing, and cancer research.
Due to its involvement in extracellular matrix organization and tissue homeostasis, understanding the function of LUM is crucial for developing therapies targeting fibrosis, tumor progression, and other pathological conditions. The LUM Antibody provided by AssayGenie offers reliable and sensitive detection of LUM protein levels, allowing researchers to further investigate its role in health and disease.
| Antibody Name: | Lum Antibody (PACO48998) |
| Antibody SKU: | PACO48998 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000 |
| Species Reactivity: | Rat |
| Immunogen: | Recombinant Rat Lumican protein (19-338AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western Blot. Positive WB detected in: Rat brain tissue. All lanes: Lum antibody at 2.5µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 39 kDa. Observed band size: 39 kDa.. |
| Background: | extracellular space, proteinaceous extracellular matrix, collagen binding, cartilage development, response to growth factor, response to organic cyclic compound |
| Synonyms: | Lumican (Keratan sulfate proteoglycan lumican) (KSPG lumican), Lum, Lcn Ldc |
| UniProt Protein Function: | LUM: a member of the small leucine-rich proteoglycan (SLRP) family that includes decorin, biglycan, fibromodulin, keratocan, epiphycan, and osteoglycin. In these bifunctional molecules, the protein moiety binds collagen fibrils and the highly charged hydrophilic glycosaminoglycans regulate interfibrillar spacings. Lumican is the major keratan sulfate proteoglycan of the cornea but is also distributed in interstitial collagenous matrices throughout the body. Lumican may regulate collagen fibril organization and circumferential growth, corneal transparency, and epithelial cell migration and tissue repair. [provided by RefSeq, Jul 2008] |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted Cellular Component: extracellular matrix; extracellular space; proteinaceous extracellular matrix; fibrillar collagen Molecular Function:collagen binding Biological Process: collagen fibril organization; visual perception; cartilage development; positive regulation of transcription from RNA polymerase II promoter; response to organic cyclic substance |
| NCBI Summary: | member of leucine-rich proteoglycan family; may play a role in immature and transient fibrosis of acute pancreatitis [RGD, Feb 2006] |
| UniProt Code: | P51886 |
| NCBI GenInfo Identifier: | 1708880 |
| NCBI Gene ID: | 81682 |
| NCBI Accession: | P51886.1 |
| UniProt Related Accession: | P51886 |
| Molecular Weight: | 38,279 Da |
| NCBI Full Name: | Lumican |
| NCBI Synonym Full Names: | lumican |
| NCBI Official Symbol: | Lum  |
| NCBI Protein Information: | lumican; KSPG lumican; keratan sulfate proteoglycan lumican |
| UniProt Protein Name: | Lumican |
| UniProt Synonym Protein Names: | Keratan sulfate proteoglycan lumican; KSPG lumican |
| Protein Family: | Lumican |
| UniProt Gene Name: | Lum  |
| UniProt Entry Name: | LUM_RAT |
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